Antioxidant metabolites from marine alga-derived fungus Aspergillus wentii EN-48
Antioxidant metabolites from marine alga-derived fungus Aspergillus wentii EN-48
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DOI：
10.1016/j.phytol.2013.11.008
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发表时间：
2014-02-01
影响因子：
1.7
通讯作者：
Wang, Bin-Gui
中科院分区：
文献类型：
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作者：
Li, Xin;Li, Xiao-Ming;Wang, Bin-Gui
从海洋藻类内生真菌文氏曲霉EtOAc提取物中鉴定了8种次生代谢物(1-8)，其中包括新的2-2-二氨基苯甲酸甲酯(2)和4-(3，4-二羟基苯甲酰胺)丁酸甲酯(2)，以及其他3种从天然来源中分离得到的衍生物(4，7和8)。通过一维和二维核磁共振实验确定了化合物的结构。每一个化合物都具有清除DPPH自由基的活性，其中一些化合物的IC50值在5.2~99.4mU g/mL之间，而阳性对照丁基羟基甲苯(BHT)的IC50值为36.9mU g/m L。(C)2013年欧洲植物化学学会。爱思唯尔出版，版权所有。
Eight secondary metabolites (1-8) including a new seco-anthraquinone (wentiquinone C, 1) and a new benzamide derivative (methyl 4-(3,4-dihydroxybenzamido) butanoate, 2), as well as three other derivatives (4, 7, and 8) that were isolated from natural source for the first time, were characterized from the EtOAc extracts of the marine alga-derived endophytic fungus Aspergillus wentii EN-48. The structures of the isolated compounds were elucidated on the basis of 1D and 2D NMR experiments. Each of the isolated compounds was evaluated for a, a-diphenyl-picrylhydrazyl (DPPH) radical scavenging activity, and some of them showed potent activities with IC50 values ranging from 5.2 to 99.4 mu g/mL, compared to the positive control, butylated hydroxytoluene (BHT), with an IC50 of 36.9 mu g/mL. (C) 2013 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.