Assessment of cancer recurrence in residual tumors after fractionated radiotherapy: a comparison of fluorodeoxyglucose, L-methionine and thymidine.
Assessment of cancer recurrence in residual tumors after fractionated radiotherapy: a comparison of fluorodeoxyglucose, L-methionine and thymidine.
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分割放射治疗后残留肿瘤的癌症复发评估：氟脱氧葡萄糖、L-蛋氨酸和胸苷的比较。
DOI：
10.1016/0969-8051(94)00099-6
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发表时间：
1997
期刊：
影响因子：
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通讯作者：
Hiroshi Yaegashi
中科院分区：
文献类型：
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作者：
Michael Reinhardt;Kazuo Kubota;S. Yamada;Ren Iwata;Hiroshi Yaegashi
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本研究评估了分次放疗后肿瘤和正常组织对脱氧葡萄糖、胸苷和蛋氨酸摄取的中期随访，以评估残留肿瘤的癌症复发情况。
方法
荷瘤 AH109A 大鼠接受 1 至 8 剂 5Gy 60Co 辐射治疗。治疗结束后6天进行18F-FDG、3H-胸苷和14C-蛋氨酸的组织分布研究、18F-FDG和14C-蛋氨酸的双示踪放射自显影以及14C标记的脱氧葡萄糖、胸苷和蛋氨酸的单示踪放射自显影。
结果
剂量反应研究表明，两次或两次以上剂量后，肿瘤对所有示踪剂的摄取显着减少，即使在后来复发的情况下也是如此。虽然 3H-Thd 和 14C-Met 肿瘤摄取与正常肌肉相似，但 18F-FDG 肿瘤摄取仍然高于肌肉，即使在肿瘤完全治愈的情况下也是如此。受照射的肌肉比未受照射的肌肉显示出更高的 18F-FDG 吸收。八次剂量后的放射自显影（100% 肿瘤治愈）显示 14C-DG 肿瘤摄取升高可归因于非恶性细胞成分，特别是坏死区域边缘的巨噬细胞层。四次和六次剂量（肿瘤治愈率分别为 33% 和 57%）后的放射自显影显示，活癌细胞中蛋氨酸和胸苷摄取量最高，而脱氧葡萄糖摄取量在活癌细胞和巨噬细胞之间没有差异。
结论
为了在放射治疗后检测和区分残留肿瘤块中的活癌细胞，使用 11C-甲硫氨酸或 11C-胸苷的 PET 可能比 18F-FDG 具有一些优势，特别是如果残留肿瘤包括较大的坏死区域。
UNLABELLED
This study evaluates the midterm follow-up of tumor and normal tissue uptake of deoxyglucose, thymidine and methionine after fractionated radiotherapy to assess cancer recurrence in residual tumors.
METHODS
AH109A tumor-burdened rats were treated with one to eight doses of 5Gy 60Co radiation. Tissue distribution study with 18F-FDG, 3H-thymidine and 14C-methionine, double-tracer autoradiography with 18F-FDG and 14C-methionine, and single-tracer autoradiography with 14C-labeled deoxyglucose, thymidine and methionine were performed 6 days after the end of therapy.
RESULTS
Dose response study shows a significant decrease of tumor uptake of all tracers after two and more doses, even in the case of later recurrence. Whereas 3H-Thd and 14C-Met tumor uptake was similar to that of normal muscle, 18F-FDG tumor uptake remains higher than that of muscle, even in the case of complete tumor cure. The irradiated muscle shows a higher 18F-FDG uptake than the nonirradiated muscle. Autoradiography after eight doses (100% tumor cure) reveals elevated 14C-DG tumor uptake to be ascribable to nonmalignant cellular elements, in particular to a macrophage layer at the rim of necrotic areas. Autoradiography after four and six doses (33% and 57% tumor cure) shows the highest methionine and thymidine uptake in viable cancer cells, whereas deoxyglucose uptake did not differ between viable cancer cells and macrophages.
CONCLUSION
To detect and differentiate viable cancer cells in a residual tumor mass after radiotherapy, PET using 11C-methionine or 11C-thymidine may have some advantages over 18F-FDG, especially if the residual tumor includes larger areas of necrosis.
Kubota, R.、Kubota, K.、Yamada, S.、Tada, M.、Ido, T.、Tamahashi, N.：“增殖和坏死前癌细胞摄取 [氟 18] 氟脱氧葡萄糖的主动和被动机制
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