Advanced tools for tissue engineering: Scaffolds, bioreactors, and signaling
Advanced tools for tissue engineering: Scaffolds, bioreactors, and signaling
复制标题
DOI：
10.1089/ten.2006.12.3285
复制
发表时间：
2006-12-01
影响因子：
--
通讯作者：
Vunjak-Novakovic, Gordana
中科院分区：
文献类型：
--
作者：
Freed, Lisa E.;Guilak, Farshid;Vunjak-Novakovic, Gordana
本文包含在“组织工程 - 下一代”研讨会第二场会议上表达的集体观点，该研讨会致力于组织工程工具：支架、生物反应器以及分子和物理信号传导。Lisa E. Freed 和 Farshid Guilak 讨论了在工程机械功能软骨和心肌的背景下，综合使用支架和生物反应器作为加速和控制组织再生的工具。EdwardGuo 重点讨论了组织工程为机械生物学研究和组织工程师需要了解组织和器官发生过程中的机械力，Martha L. Gray 重点关注了生物医学成像在工程组织无创监测方面的潜力，以及生物医学成像为开发新标记物带来的机会，Robert Tranquillo 回顾了一系列无血管习惯性负载组织的组织工程方法，包括血管、心脏瓣膜、韧带、肌腱、软骨和皮肤，他提出了“反向范例”的观点。细胞-基质相互作用、细胞力学、基质力学和力学生物学定量研究中的组织结构。 Milica Radisic 以同步收缩心肌为例讨论了组织工程系统的仿生设计。 Michael V. Sefton 提出了一种新的、简单的工程组织血管化方法。本次会议强调了对先进支架、生物反应器和成像技术的需求，并提供了许多启发性的例子，说明如何利用这些先进工具进行功能组织工程以及医学和生物学基础研究。
This article contains the collective views expressed at the second session of the workshop "Tissue Engineering - The Next Generation,'' which was devoted to the tools of tissue engineering: scaffolds, bioreactors, and molecular and physical signaling. Lisa E. Freed and Farshid Guilak discussed the integrated use of scaffolds and bioreactors as tools to accelerate and control tissue regeneration, in the context of engineering mechanically functional cartilage and cardiac muscle. Edward Guo focused on the opportunities that tissue engineering generates for studies of mechanobiology and on the need for tissue engineers to learn about mechanical forces during tissue and organ genesis. Martha L. Gray focused on the potential of biomedical imaging for noninvasive monitoring of engineered tissues and on the opportunities biomedical imaging can generate for the development of new markers. Robert Tranquillo reviewed the approach to tissue engineering of a spectrum of avascular habitually loaded tissues blood vessels, heart valves, ligaments, tendons, cartilage, and skin. Jeffrey W. Holmes offered the perspective of a "reverse paradigm'' - the use of tissue constructs in quantitative studies of cell-matrix interactions, cell mechanics, matrix mechanics, and mechanobiology. Milica Radisic discussed biomimetic design of tissue-engineering systems, on the example of synchronously contractile cardiac muscle. Michael V. Sefton proposed a new, simple approach to the vascularization of engineered tissues. This session stressed the need for advanced scaffolds, bioreactors, and imaging technologies and offered many enlightening examples on how these advanced tools can be utilized for functional tissue engineering and basic research in medicine and biology.