Developmental sequelae and neurophysiologic substrates of sensory seeking in infant siblings of children with autism spectrum disorder
Developmental sequelae and neurophysiologic substrates of sensory seeking in infant siblings of children with autism spectrum disorder
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DOI：
10.1016/j.dcn.2017.08.005
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发表时间：
2018-01-01
影响因子：
4.7
通讯作者：
Cascio, Carissa J.
中科院分区：
文献类型：
--
作者：
Damiano-Goodwin, Cara R.;Woynaroski, Tiffany G.;Cascio, Carissa J.
有人提出，感觉反应的早期差异来自非典型的神经功能，并对跨领域的发展产生级联效应。这项纵向研究前瞻性地跟踪了自闭症谱系障碍（ASD）风险增高的婴儿，这些婴儿是被诊断患有ASD的儿童的弟弟妹妹（同胞-ASD）和ASD风险相对较低的婴儿（典型发育儿童的同胞;同胞TD），以检查特定感觉反应模式的发育后遗症和可能的神经生理学基础：对非社会性感官刺激或"感官寻求"有异常强烈的兴趣。"在18个月时，感官寻求和社会定向是用感官处理评估来测量的，感官寻求的潜在神经特征（即，额叶α不对称性）通过静息状态脑电图测量。在36个月时，在综合诊断评估中评估婴儿的社会行为学。同胞ASD表现出升高的感觉寻求相对于同胞TD，增加感觉寻求同时与减少跨群体的社会定向和休息额不对称的同胞ASD。感官寻求也预示了后来的社会行为学。研究结果表明，感觉寻求可能会产生级联效应的社会发展的婴儿在ASD的风险和非典型的额叶不对称性可能是这种非典型模式的感觉反应。
It has been proposed that early differences in sensory responsiveness arise from atypical neural function and produce cascading effects on development across domains. This longitudinal study prospectively followed infants at heightened risk for autism spectrum disorder (ASD) based on their status as younger siblings of children diagnosed with ASD (Sibs-ASD) and infants at relatively lower risk for ASD (siblings of typically developing children; Sibs-TD) to examine the developmental sequelae and possible neurophysiological substrates of a specific sensory response pattern: unusually intense interest in nonsocial sensory stimuli or "sensory seeking." At 18 months, sensory seeking and social orienting were measured with the Sensory Processing Assessment, and a potential neural signature for sensory seeking (i.e., frontal alpha asymmetry) was measured via resting state electroencephalography. At 36 months, infants' social symptomatology was assessed in a comprehensive diagnostic evaluation. Sibs-ASD showed elevated sensory seeking relative to Sibs-TD, and increased sensory seeking was concurrently associated with reduced social orienting across groups and resting frontal asymmetry in Sibs-ASD. Sensory seeking also predicted later social symptomatology. Findings suggest that sensory seeking may produce cascading effects on social development in infants at risk for ASD and that atypical frontal asymmetry may underlie this atypical pattern of sensory responsiveness.