A comparison study of macrocyclic hosts functionalized reduced graphene oxide for electrochemical recognition of tadalafil
A comparison study of macrocyclic hosts functionalized reduced graphene oxide for electrochemical recognition of tadalafil
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DOI：
10.1016/j.bios.2016.07.016
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发表时间：
2017-03-15
影响因子：
12.6
通讯作者：
Li, Can-Peng
中科院分区：
文献类型：
--
作者：
Zhao, Hui;Yang, Long;Li, Can-Peng
本工作描述了β-环糊精（β-CD）和对磺化杯[6]芳烃（SCX 6）功能化的还原氧化石墨烯（RGO）对他达拉非的识别的比较。在本研究中，他达拉非和两种大环化合物（β-CD和SCX 6）分别被选为客体和主体分子。通过紫外光谱和分子模拟计算研究了β-CD/他达拉非和SCX 6/他达拉非的包合物，证明了SCX 6对他达拉非的超分子识别能力高于β-CD。通过湿化学方法制备了β-CD @RGO和SCX6@RGO复合材料。采用傅里叶变换红外光谱、热重分析、原子力显微镜和zeta电位对复合材料进行了表征。SCX6@RGO表现出比β-CD @RGO更高的电化学响应，这是由于SCX 6比β-CD具有更高的识别能力。结合SCX 6和RGO的优点，基于SCX6@RGO纳米杂化物构建了一个灵敏的电化学传感平台。该方法的线性响应范围为0.1-50 μ M和50-1000 μ M，检出限为0.045 μ M（S/N=3）。该传感平台成功地用于测定中草药性保健品和加标人血清样品中的他达拉非，表明其有前途的痕量他达拉非测定的分析应用。(C)2016爱思唯尔B. V.保留所有权利。
The present work described the comparison of beta-cyclodextrin (beta-CD) and p-sulfonated calix[6]arene (SCX6) functionalized reduced graphene oxide (RGO) for recognition of tadalafil. In this study, tadalafil and two macrocycles (beta-CD and SCX6) were selected as the guest and host molecules, respectively. The inclusion complexes of (beta-CD/tadalafil and SCX6/tadalafil were studied by UV spectroscopy and molecular simulation calculations, proving the higher supermolecular recognition capability of SCX6 than beta-CD towards tadalafil. The beta-CD@RGO and SCX6@RGO composites were prepared by a wet-chemical route. The obtained composites were characterized by Fourier transform infrared spectrometry, thermogravimetric analysis, atomic force microscopy, and zeta potential. The SCX6@RGO showed a higher electrochemical response than beta-CD@RGO, which was caused by the higher recognition capability of SCX6 than beta-CD. By combining the merits of SCX6 and the RGO, a sensitive electrochemical sensing platform was developed based on the SCX6@RGO nanohybrids. A linear response range of 0.1-50 mu M and 50-1000 mu M for tadalafil with a low detection limit of 0.045 mu M (S/N=3) was obtained by using this method. The constructed sensing platform was successfully used to determine tadalafil in herbal sexual health products and spiked human serum samples, suggesting its promising analytical applications for the trace level determination of tadalafil. (C) 2016 Elsevier B.V. All rights reserved.