Enhancing fluorescence detection with a photonic crystal structure in a total-internal-reflection configuration
Enhancing fluorescence detection with a photonic crystal structure in a total-internal-reflection configuration
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DOI：
10.1364/ol.33.001729
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发表时间：
2008-08-01
期刊：
影响因子：
3.6
通讯作者：
Ishikawa, Mitsuru
中科院分区：
文献类型：
--
作者：
Ye, Jing Yong;Ishikawa, Mitsuru
与先前报道的嵌入光子晶体结构中的荧光团的荧光增强相反[Appl。物理。莱特。 75, 3605 (1999)]，在这封信中，我们展示了一种在全内反射几何结构中使用一维光子晶体形成开放微腔的独特方法。这种配置为增强荧光成像和生物传感提供了可能性。已经对固定在开放腔上的荧光团进行了时间分辨荧光检测。观察到超过 20 倍的荧光增强。 (C) 2008 年美国光学学会。
In contrast to fluorescence enhancement of fluorophores embedded in a photonic crystal structure as previously reported [Appl. Phys. Lett. 75, 3605 (1999)], in this Letter we demonstrate a unique approach to forming an open microcavity using a one-dimensional photonic crystal in a total-internal-reflection geometry. This configuration opens up the possibility for enhancing fluorescence imaging and biosensing. Time-resolved fluorescence detection of fluorophores immobilized on the open cavity has been carried out. Over 20-fold fluorescence enhancement was observed. (C) 2008 Optical Society of America.