Effects and Mechanisms of Resveratrol on Aging and Age-Related Diseases.
Effects and Mechanisms of Resveratrol on Aging and Age-Related Diseases.
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DOI：
10.1155/2021/9932218
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发表时间：
2021
影响因子：
--
通讯作者：
Li HB
中科院分区：
文献类型：
--
作者：
Zhou DD;Luo M;Huang SY;Saimaiti A;Shang A;Gan RY;Li HB
人口老龄化问题因其快速增长而成为人们关注的问题。衰老是许多慢性病的重要危险因素。白藜芦醇可以在许多食物中找到，如葡萄，红酒，花生和蓝莓。研究表明，白藜芦醇具有抗氧化、抗炎、心血管保护、抗癌、抗糖尿病、减肥、神经保护、抗衰老等多种生物活性。白藜芦醇的抗衰老机制主要是改善氧化应激、减轻炎症反应、改善线粒体功能和调节细胞凋亡。白藜芦醇可能是一种安全有效的抗衰老药物。本文综述了白藜芦醇对衰老、延长寿命和几种与年龄有关的疾病的影响，并着重介绍了其抗衰老作用的机制。
The aging of population has become an issue of great concern because of its rapid increase. Aging is an important risk factor of many chronic diseases. Resveratrol could be found in many foods, such as grapes, red wine, peanuts, and blueberries. Many studies reported that resveratrol possessed various bioactivities, such as antioxidant, anti-inflammatory, cardiovascular protection, anticancer, antidiabetes mellitus, antiobesity, neuroprotection, and antiaging effects. The antiaging mechanisms of resveratrol were mainly ameliorating oxidative stress, relieving inflammatory reaction, improving mitochondrial function, and regulating apoptosis. Resveratrol could be an effective and safe compound for the prevention and treatment of aging and age-related diseases. In this review, we summarize the effects of resveratrol on aging, life extension, and several age-related diseases, with special attention paid to the mechanisms of antiaging action.
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影响因子：
168.9
作者：
Bloom, David E.;Chatterji, Somnath;Kowal, Paul;Lloyd-Sherlock, Peter;Mckee, Martin;Rechel, Bernd;Rosenberg, Larry;Smith, James P.
通讯作者：
Smith, James P.
白藜芦醇通过上调人脐静脉内皮细胞自噬来减轻过氧化氢引起的衰老
影响因子：
4.8
作者：
Du, Ligen;Chen, Enping;Wu, Saizhu
通讯作者：
Wu, Saizhu
影响因子：
5.6
作者：
Chen CC;Chang ZY;Tsai FJ;Chen SY
通讯作者：
Chen SY
DOI：
10.1038/s41569-018-0064-2
发表时间：
2018-09
期刊：
Nature reviews. Cardiology
影响因子：
--
作者：
Ferrucci L;Fabbri E
通讯作者：
Fabbri E
影响因子：
64.8
作者：
Baur, Joseph A.;Pearson, Kevin J.;Sinclair, David A.
通讯作者：
Sinclair, David A.