The other functions of the sodium pump
The other functions of the sodium pump
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DOI：
10.1016/j.ceca.2019.102105
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发表时间：
2019-12-01
期刊：
影响因子：
4
通讯作者：
Askari, Amir
中科院分区：
文献类型：
--
作者：
Askari, Amir
Na/K-ATP酶（钠泵）是在20世纪50年代发现的质膜酶，其几乎在所有真核细胞的膜上进行Na+和K+的偶联主动转运。直到20世纪90年代，人们才发现Na/K-ATP酶除了泵送离子外，还能够与邻近蛋白质发生刺激诱导的相互作用，从而激活信号转导途径，导致细胞生长。本文就近二三十年来钠泵信号功能的研究进展作一综述。涵盖的主题包括：（a）有争议的洋地黄诱导的生长激活通过表皮生长因子受体和Src激酶在心肌细胞和其他几种细胞类型;（B）洋地黄诱导的生长激活在心肌细胞和其他细胞类型通过磷脂酰肌醇3-激酶的广泛发现;和（c）一些有趣的，但研究不够的钠泵信号功能。
Na/K-ATPase (the sodium pump) was discovered in the 1950s as the plasma membrane enzyme that carries out the coupled active transports of Na+ and K+ across the membranes of nearly all eukaryotic cells. It was not until the 1990s when it was shown that besides pumping ions, Na/K-ATPase is also capable of stimulus-induced interactions with neighboring proteins that lead to activations of signal transduction pathways causing cell growth. This article is an attempt to review the progress of the research on these signaling functions of sodium pump during the past 2-3 decades. The covered topics include (a) the controversial digitalis-induced growth activations through the epidermal growth factor receptor and Src kinase in cardiac myocytes and several other cell types; (b) the extensive findings on digitalis-induced growth activations in cardiac myocytes and other cell types through phosphatidylinositol 3-kinases; and (c) a number of interesting but insufficiently studied signaling functions of the sodium pump.