A novel array chip to monitor in situ composite degradation using electrochemical impedance spectroscopy.
A novel array chip to monitor in situ composite degradation using electrochemical impedance spectroscopy.
复制标题
一种利用电化学阻抗谱监测原位复合材料降解的新型阵列芯片。
DOI：
10.1016/j.dental.2011.04.006
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Wolter,ScottD
中科院分区：
文献类型：
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作者：
Stoner,BrianR;Piascik,JeffreyR;Brown,Billyde;Wolter,ScottD
目的提出一种新的阵列芯片技术，用于原位监测牙科复合材料的物理性能。DECAY芯片（Degradation via ElectrochemicalArray）利用微加工技术构建一个均匀的凹进威尔斯阵列，可以填充牙科修复材料（如复合材料或汞合金）和电化学分析solution.MethodsThe阵列能够在一个共同的基板上均匀制备多个标本和参考对照，所有这些都可以同时进行评估。这里提出的DECAY芯片由一个3 × 3阵列的100 μm深的威尔斯，并用于监测降解的一种常见的牙科复合材料作为一个函数的time.ResultsThe数据相关的变化测量的介电性能的表面和体积变化的复合材料是暴露于乙醇：DI混合物（75%乙醇）。该系统的模型，是未来的计划，以简化快速材料筛选和在vitroanalysis.SignificanceThisin原位诊断芯片的方法将使评估的复合材料标本，在广泛的模拟口腔环境下进行测试。它还可以作为新复合材料配方的筛选平台，并有助于材料降解和失效机制的研究。
ObjectivesThis paper presents a novel array-chip technology used to monitor the physical properties of dental compositesin situ. The DECAY chip (Degradation viaElectrochemicalArray) leverages microfabrication techniques to construct a uniform array of recessed wells that may be filled with dental restorative materials (e.g. composite or amalgam) and analyzed electrochemically in solution.MethodsThe array enables the uniform preparation of multiple specimens and reference controls on a common substrate, all of which may be simultaneously evaluated. The DECAY-chip presented here consists of a 3 × 3 array of 100 μm deep wells, and is used to monitor the degradation of a common dental composite as a function of time.ResultsThe data correlate changes in the measured dielectric properties to surface and bulk changes as the composite is exposed to an ethanol:DI mixture (75% ethanol). A model for the system is presented, as are future plans to simplify the methodology for rapid materials screening andin vitroanalyses.SignificanceThisin situdiagnostic chip will enable evaluation of composite specimens, tested under a wide range of simulated oral environments. It may also serve as a screening platform for new composite formulations and aid in the study of materials degradation and failure mechanisms.