Glucocorticoid effects on object recognition memory require training-associated emotional arousal
Glucocorticoid effects on object recognition memory require training-associated emotional arousal
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DOI：
10.1073/pnas.0307803100
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发表时间：
2004-01-20
影响因子：
11.1
通讯作者：
McGaugh, JL
中科院分区：
文献类型：
--
作者：
Okuda, S;Roozendaal, B;McGaugh, JL
大量证据表明糖皮质激素参与记忆巩固和记忆恢复的调节。本实验研究了这些激素对记忆的影响是否取决于训练经验引起的情绪唤醒水平。我们研究了这个问题，在雄性Sprague-Dawley大鼠的影响，立即训练后全身注射糖皮质激素皮质酮对物体识别记忆的两种条件下，不同的训练相关的情绪唤起。在先前未习惯于实验环境的大鼠中，皮质酮（0.3、1.0或3.0 mg/kg，s.c.）在3分钟训练试验后立即给药，以倒U形剂量-反应关系增强了24小时的保持性能。相比之下，皮质酮不影响24小时保留的大鼠，接受广泛的先前习惯的实验环境，因此，减少了新奇诱导的情绪唤起训练过程中。此外，立即posttraining管理的皮质酮nonhabitated大鼠，在剂量，增强24小时的保留，损害物体识别性能在1小时的保留时间间隔，而皮质酮训练后管理的良好习惯的大鼠没有损害1小时的保留。因此，本研究结果表明，训练引起的情绪唤醒可能是必不可少的糖皮质激素对物体识别记忆的影响。
Considerable evidence implicates glucocorticoid hormones in the regulation of memory consolidation and memory retrieval. The present experiments investigated whether the influence of these hormones on memory depends on the level of emotional arousal induced by the training experience. We investigated this issue in male Sprague-Dawley rats by examining the effects of immediate posttraining systemic injections of the glucocorticoid corticosterone on object recognition memory under two conditions that differed in their training-associated emotional arousal. In rats that were not previously habituated to the experimental context, corticosterone (0.3, 1.0, or 3.0 mg/kg, s.c.) administered immediately after a 3-min training trial enhanced 24-hr retention performance in an inverted-U shaped dose-response relationship. In contrast, corticosterone did not affect 24-hr retention of rats that received extensive prior habituation to the experimental context and, thus, had decreased novelty-induced emotional arousal during training. Additionally, immediate posttraining administration of corticosterone to nonhabituated rats, in doses that enhanced 24-hr retention, impaired object recognition performance at a 1-hr retention interval whereas corticosterone administered after training to well-habituated rats did not impair 1-hr retention. Thus, the present findings suggest that training-induced emotional arousal may be essential for glucocorticoid effects on object recognition memory.