In vitro degradation behavior of Mg scaffolds with three-dimensional interconnected porous structures for bone tissue engineering
In vitro degradation behavior of Mg scaffolds with three-dimensional interconnected porous structures for bone tissue engineering
复制标题
用于骨组织工程的具有三维互连多孔结构的镁支架的体外降解行为
DOI：
10.1016/j.corsci.2018.09.001
复制
发表时间：
2018-11-01
影响因子：
8.3
通讯作者：
Feyerabend, Frank
中科院分区：
文献类型：
--
作者：
Jia, Gaozhi;Chen, Chenxin;Feyerabend, Frank
研究了两种具有不同三维互联多孔结构的Mg支架在考虑孔支撑和连通性的情况下的降解行为。随着孔壁上沉积形成的堵塞，两个支架的连通性逐渐降低。具有球形孔和弧形孔柱的Mg支架比具有不规则孔和多边形孔柱的Mg支架降解速度更快，但具有更好的抗连通性退化能力。MC3T3-E1成骨细胞在两种支架上的直接细胞培养具有良好的骨组织工程应用前景。
The degradation behavior in consideration of the pore strut and the interconnectivity of two Mg scaffolds with different three-dimensional interconnected porous structures were evaluated. The interconnectivity of the two scaffolds gradually decreased along with the clogged interconnected pores due to the deposition formation on the pore wall. Mg scaffold with spherical pores and cambered pore strut degraded faster but exhibited better resistance to the deterioration of the interconnectivity compared with Mg scaffold with irregular pores and polygonal pore struts. Direct cell culture of MC3T3-E1 osteoblasts on the two scaffolds indicated a promising potential for bone tissue engineering.