Long-term Efficacy of Interferon in Severe Uveitis Associated with Behcet Disease
Long-term Efficacy of Interferon in Severe Uveitis Associated with Behcet Disease
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DOI：
10.1080/09273948.2016.1206204
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发表时间：
2017-01-01
影响因子：
3.3
通讯作者：
Bodaghi, Bahram
中科院分区：
文献类型：
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作者：
Diwo, Eleonore;Gueudry, Julie;Bodaghi, Bahram
目的：回顾性评估的频率，眼睛复发和长期缓解的可能性，在患者用干扰素（IFN）治疗严重葡萄膜炎与Behcet diseases.Methods：所有患者治疗的初始剂量为300万IU IFN每周三次。主要结果的措施是复发的人数，每人每年前，期间，和后IFN treatment.Results：36例（67眼），31（86.1%）响应IFN。平均随访8.19年。36例患者中有21例停用IFN，其中76%在停用后5.05年内未复发。在治疗期间，平均每人每年的复发率从1.39显著下降到0.0496（p = 1.82x10（-10）），在IFN停药后，平均每人每年的复发率保持在0.057。
Purpose: To retrospectively assess the frequency of ocular relapse and the possibility of long-term remission in patients treated with interferon (IFN) for severe uveitis associated with Behcet disease.Methods: All patients were treated with an initial dosage of 3 million IU IFN three times a week. The main outcome measure was the number of relapses per person per year before, during, and after IFN treatment.Results: Of 36 patients (67 eyes), 31 (86.1%) responded to IFN. The mean follow-up was 8.19 years. Twenty-one out of 36 patients discontinued IFN and 76% of these have not relapsed within 5.05 years after discontinuation. The mean relapse per person per year decreased significantly from 1.39 to 0.0496 (p = 1.82x10(-10)) during the treatment period and remained at 0.057 relapses per person per year after IFN discontinuation.Conclusion: IFN efficiently decreases the relapse rate and seems to permit long-term remission even after discontinuation.