One-year recurrence rate of Graves ophthalmopathy presenting as diplopia in the primary position after varied doses of intravenous methylprednisolone followed by oral prednisolone with dosing based on the magnetic resonance imaging findings
One-year recurrence rate of Graves ophthalmopathy presenting as diplopia in the primary position after varied doses of intravenous methylprednisolone followed by oral prednisolone with dosing based on the magnetic resonance imaging findings
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根据磁共振成像结果，静脉注射不同剂量的甲基泼尼松龙，然后口服泼尼松龙后，表现为原发性复视的 Graves 眼病的一年复发率
DOI：
10.1007/s10384-022-00954-9
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发表时间：
2022
影响因子：
2.4
通讯作者：
Fukuchi Takeo
中科院分区：
文献类型：
--
作者：
Ueki Satoshi;Hasegawa Yukari;Hatase Tetsuhisa;Kiyokawa Megumi;Fukuchi Takeo
目的揭示以复视为主的格雷夫斯眼病（GO）在不同剂量静脉注射甲基泼尼松龙（IVMP）后口服泼尼松龙后1年的复发率，剂量基于磁共振成像（MRI）结果。研究设计回顾性研究。方法我们分析了25例患者的病历。 诊断为新发 GO 并在我院一线接受复视治疗的患者。治疗包括 MRI 确定的不同剂量的 IVMP，然后口服泼尼松龙。如果 6 g IVMP 后 MRI 结果显示恶化或无变化，则添加 3 g IVMP 进一步治疗。进行简单和多元线性回归分析以揭示自变量和因变量（定义为复发）之间的关联。结果患者平均年龄（±标准差）为61.3±11.3岁。男女比例为15：10。 25 名患者中的 21 名患者总共接受了 6 克 IVMP，而其余 4 名患者总共接受了 9 克 IVMP。 5 名患者 (20%) 在 IVMP 给药后 1 年内复发 GO。简单和多元线性回归分析显示，6 g IVMP 后的 MRI 结果影响复发（P< .05）。结论本研究表明，20% 的患者在给予不同剂量 IVMP 后 1 年内 GO 复发，剂量基于 MRI 结果。此外，在 6 g IVMP 后使用 MRI 评估炎症在预测复发方面具有潜在作用。
PurposeTo reveal the recurrence rate of Graves ophthalmopathy (GO) presenting as diplopia in the primary position for 1 year after varied doses of intravenous methylprednisolone (IVMP) followed by oral prednisolone, with dosing based on the magnetic resonance imaging (MRI) findings.Study designRetrospective study.MethodsWe analyzed the medical charts of 25 patients who were diagnosed with new-onset GO and who received treatment for diplopia in the primary position at our hospital. Treatment consisted of MRI-determined varied doses of IVMP followed by oral prednisolone. If the MRI findings showed deterioration or were unchanged after 6 g of IVMP, 3 g of IVMP was added for further treatment. Simple and multiple linear regression analyses were performed to reveal the associations between the independent variables and the dependent variable, defined as recurrence.ResultsThe mean patient age (± standard deviation) was 61.3 ± 11.3 years. The female to male ratio was 15:10. Twenty-one of the 25 patients received a total of 6 g of IVMP, whilst the remaining 4 patients received a total of 9 g of IVMP. In 5 patients (20%), the GO recurred within 1 year of IVMP administration. Simple and multiple linear regression analyses showed that the MRI findings after 6 g of IVMP affected recurrence (P< .05).ConclusionThis study showed that in 20% of patients, GO recurred within 1 year of administration of varied doses of IVMP, with the dosing based on the MRI findings. Furthermore, assessment of inflammation by use of MRI after 6 g of IVMP has a potential role in predicting recurrence.
影响因子：
39.2
作者：
Bartalena, L;Marcocci, C;Pinchera, A
通讯作者：
Pinchera, A