Magnetite nanoparticles for cancer diagnosis, treatment, and treatment monitoring: recent advances.
Magnetite nanoparticles for cancer diagnosis, treatment, and treatment monitoring: recent advances.
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DOI：
10.1016/j.mattod.2015.08.022
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发表时间：
2016-04
期刊：
影响因子：
--
通讯作者：
Zhang M
中科院分区：
文献类型：
--
作者：
Revia RA;Zhang M
在过去的二十年中，用于肿瘤疾病检测和治疗的各个方面的纳米颗粒（NPs）的开发已经取得了巨大进展。纳米颗粒已经被定制为用作成像的对比度增强剂、药物递送载体，并且最近被用作在磁性和光子消融疗法中引发肿瘤细胞死亡的治疗组分。在NP的许多可能的核心成分中，例如金、银、碳纳米管、富勒烯、氧化锰、脂质、胶束等，基于氧化铁（或磁铁矿）的NP由于其优异的超顺磁性、生物相容性和生物可降解性而被广泛研究。本文综述了近年来磁铁矿纳米粒子在癌症诊断、治疗和治疗监测中的应用。最后，将讨论有关氧化铁纳米颗粒的毒性和临床转化的一些观点，以及纳米颗粒开发的未来前景，以促进癌症治疗诊断学的单一制剂中的多种疗法。
The development of nanoparticles (NPs) for use in all facets of oncological disease detection and therapy has shown great progress over the past two decades. NPs have been tailored for use as contrast enhancement agents for imaging, drug delivery vehicles, and most recently as a therapeutic component in initiating tumor cell death in magnetic and photonic ablation therapies. Of the many possible core constituents of NPs, such as gold, silver, carbon nanotubes, fullerenes, manganese oxide, lipids, micelles, etc., iron oxide (or magnetite) based NPs have been extensively investigated due to their excellent superparamagnetic, biocompatible, and biodegradable properties. This review addresses recent applications of magnetite NPs in diagnosis, treatment, and treatment monitoring of cancer. Finally, some views will be discussed concerning the toxicity and clinical translation of iron oxide NPs and the future outlook of NP development to facilitate multiple therapies in a single formulation for cancer theranostics.