Interlinked fast and slow positive feedback loops drive reliable cell decisions
Interlinked fast and slow positive feedback loops drive reliable cell decisions
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DOI：
10.1126/science.1113834
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发表时间：
2005-10-21
期刊：
影响因子：
56.9
通讯作者：
Meyer, T
中科院分区：
文献类型：
--
作者：
Brandman, O;Ferrett, JE;Meyer, T
正反馈是一种普遍存在的信号转导基序，它允许系统将分级输入转换为决定性的全或无输出。在这里，我们调查为什么正反馈开关，调节极化的芽殖酵母，钙信号，非洲爪蟾卵母细胞成熟，和其他各种过程中使用多个相互关联的循环，而不是单一的正反馈循环。数学模拟表明，连接快速和stow正反馈回路创建了一个“双时间”开关，该开关既可快速诱导，又能抵抗上游信号系统中的噪声。
Positive feedback is a ubiquitous signal transduction motif that allows systems to convert graded inputs into decisive, all-or-none outputs. Here we investigate why the positive feedback switches that regulate polarization of budding yeast, calcium signaling, Xenopus oocyte maturation, and various other processes use multiple interlinked loops rather than single positive feedback loops. Mathematical simulations revealed that linking fast and stow positive feedback loops creates a "dual-time" switch that is both rapidly inducible and resistant to noise in the upstream signaling system.