Do nociceptive signals from the pancreas travel in the dorsal column?
Do nociceptive signals from the pancreas travel in the dorsal column?
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DOI：
10.1016/s0304-3959(00)00364-x
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发表时间：
2001-01-01
期刊：
影响因子：
7.4
通讯作者：
Westlund, KN
中科院分区：
文献类型：
--
作者：
Houghton, AK;Wang, CC;Westlund, KN
中线背柱损伤已被证明是缓解患者盆腔内脏疼痛的有效外科治疗方法。本研究的目的是观察背柱损毁对麻醉大鼠胰腺表面应用缓激肽引起的丘脑腹侧后外侧核神经元电生理反应的增强，以及(Ii)胰腺注射缓激肽后痛行为的影响。在戊巴比妥麻醉的大鼠中。用钨电极对单个丘脑神经元进行记录。在胰腺表面短暂应用缓激肽(10微克/毫升)，可使记录到的约20%的神经元放电频率增加。背柱损毁或鞘内注射吗啡可显著降低胰腺缓激肽对丘脑神经元的兴奋作用。在另一组大鼠中，通过先前植入的导管将缓激肽注入胰腺，导致探索行为减少，其他疼痛相关行为增加，如舔腹部。在注射缓激肽前(1周)进行背柱损毁可以减少探索行为的减少，但不能使探索行为恢复到对照水平。总之，传递到丘脑的有关胰腺的伤害性信息是从脊髓通过背柱传递的，可能是通过突触后背柱通路。然而，背柱通路可能不是传递有关胰腺伤害性刺激的信息的唯一途径，特别是影响复杂行为反应的信息。(C)2001年国际疼痛研究协会。爱思唯尔科学公司出版。版权所有。
A midline dorsal column lesion has been shown to be an effective surgical treatment for the relief of pelvic visceral pain in patients. The aim of this study was to examine the effectiveness of a dorsal column lesion upon: (i) increased electrophysiological responses of neurons in the ventral posterolateral thalamic nucleus in anesthetized rats evoked by the application of bradykinin to the surface of the pancreas, and (ii) pain-related behaviors observed after pancreatic infusion with bradykinin. In rats anesthetized with pentobarbital. recordings from individual thalamic neurons were made using tungsten electrodes. Brief application of bradykinin (10 mug/ml) to the surface of the pancreas resulted in an increased firing rate in approximately 20% of neurons recorded. A dorsal column lesion or intrathecal administration of morphine greatly reduced the excitatory effects of pancreatic bradykinin application on thalamic neurons. In a separate group of rats, bradykinin was infused into the pancreas through a previously implanted catheter resulting in a decrease in exploratory behavior and an increase in other pain-related behaviors, e.g. licking of the abdomen. A dorsal column lesion made prior (1 week) to the bradykinin infusion reduced the decrease in exploratory behavior but did not return exploratory behavior to control levels. In conclusion, nociceptive information relayed to the thalamus about the pancreas is transmitted from the spinal cord through the dorsal columns, possibly by the post-synaptic dorsal column pathway. However, the dorsal column pathway may not be the sole route for relaying information about noxious stimulation of the pancreas, particularly that impacting complex behavioral responses. (C) 2001 International Association for the Study of Pain. Published by Elsevier Science B.V. All rights reserved.