Is more better? A comparison of tri- and tetrapeptidic catalysts.
Is more better? A comparison of tri- and tetrapeptidic catalysts.
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越多越好吗？
DOI：
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发表时间：
2017
影响因子：
3.2
通讯作者：
H. Wennemers
中科院分区：
文献类型：
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作者：
T. Schnitzer;M. Wiesner;P. Krattiger;J. Revell;H. Wennemers
从酶的角度来看，有一个普遍的概念，催化活性肽越大越复杂越像酶，它应该变得越好。但这是真的吗？我们首先通过筛选催化醛醇反应的三肽和四肽的分裂和混合文库来解决这个问题。然后比较了H-Pro-Pro-Glu/Asp-NH2和H-Pro-Pro-Glu/Asp-Pro-NH2型相关三、四肽型催化剂所有可能的非对映异构体在醛醇和共轭加成反应中的催化性能。
From an enzymatic perspective, there is a general notion that the bigger and more complex a catalytically active peptide is the more enzyme-like and the better it should become. But is this really true? We have tackled this question firstly by screening split-and-mix-libraries of tri- and tetrapeptides for members that catalyze aldol reactions. Then, the catalytic performance of all possible diastereoisomers of related tri- and tetrapeptidic catalysts of the type H-Pro-Pro-Glu/Asp-NH2 and H-Pro-Pro-Glu/Asp-Pro-NH2 in aldol and conjugate addition reactions was compared.
DOI：
10.1002/anie.201505898
发表时间：
2015-09-14
期刊：
Angewandte Chemie (International ed. in English)
影响因子：
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作者：
Shugrue CR;Miller SJ
通讯作者：
Miller SJ