Broad intrinsic functional connectivity boundaries of the macaque prefrontal cortex
Broad intrinsic functional connectivity boundaries of the macaque prefrontal cortex
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DOI：
10.1016/j.neuroimage.2013.11.024
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发表时间：
2014-03-01
期刊：
影响因子：
5.7
通讯作者：
Evening, Stefan
中科院分区：
文献类型：
--
作者：
Hutchison, R. Matthew;Evening, Stefan
根据细胞构筑特性，灵长类前额叶皮质被划分为不同的亚区，显示出独特的结构连接模式，并不断努力提供更细粒度的划分。虽然在亚毫米范围内可能会发现有意义的划分，但子划分存在于整个分层体系结构中，并且在较高级别上可能共享类似的活动模式和功能。在这里，我们在轻度麻醉的猕猴身上使用静息状态的功能磁共振成像来测量前额叶皮质的内在功能连接。在大体解剖学层面上，数据驱动的方法揭示了五个广泛的簇，显示出明显的全脑功能连接。虽然每个簇包含几个细胞结构亚区，但这些簇与前额叶皮质的内在结构连接重叠，每个簇可能具有共同的功能。(C)2013 Elsevier Inc.保留所有权利。
Based upon cytoarchitectonic properties, the primate prefrontal cortex has been partitioned into different subregions that show unique structural connectivity patterns, with ongoing efforts to provide more fine-grained divisions. While meaningful divisions may be found within the sub-millimeter range, the subdivisions exist within an overall hierarchical architecture and at higher levels likely share similar activity patterns and functionality. Here, we used resting-state fMRI in lightly anesthetized macaque monkeys to measure the intrinsic functional connectivity of the prefrontal cortex. At a gross anatomical level, the data driven approach revealed five broad clusters that showed distinct brain-wide functional connectivity. Although each cluster encompasses several cytoarchitectonic subregions, the clusters overlap with the intrinsic structural connectivity of the prefrontal cortex and each cluster may subserve common functions. (C) 2013 Elsevier Inc. All rights reserved.