EFFECT OF COLD ISCHEMIA TIME ON THE EARLY OUTCOME OF HUMAN HEPATIC ALLOGRAFTS PRESERVED WITH UW SOLUTION
EFFECT OF COLD ISCHEMIA TIME ON THE EARLY OUTCOME OF HUMAN HEPATIC ALLOGRAFTS PRESERVED WITH UW SOLUTION
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DOI：
10.1097/00007890-199105000-00013
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发表时间：
1991-05-01
期刊：
影响因子：
6.2
通讯作者：
STARZL, TE
中科院分区：
文献类型：
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作者：
FURUKAWA, H;TODO, S;STARZL, TE
1987年10月24日至1989年5月19日期间，593个尸体肝脏被用于原发性肝移植。接枝采用冷电解液原位冷却和UW溶液背台冲洗相结合的方法制备。平均冷缺血时间为12.8（2.4 ~ 34.7）小时。按冷缺血时间分为5组：1组< 10小时（223例）；第二组：10-14小时（n = 188）；第三组：15-19小时（n = 101）；第4组：20-24小时（n = 52）；第五组：大于或等于25小时（n = 29）。5组患者1年生存率、术后第1周SGOT最高、术后第1个月SGOT和总胆红素差异无统计学意义。然而，通过logistic回归模型，随着冷缺血时间的延长，再移植率（P = 0.001）和原发性无功能率（P = 0.006）显著上升，这意味着患者生存的等效性越来越依赖于积极的再移植。
Five hundred ninety-three cadaveric livers were used for primary liver transplantation between October 24, 1987, and May 19, 1989. The grafts were procured with a combined method, using in situ cooling with cold electrolyte solution and backtable flushing with UW solution. The mean cold-ischemia time was 12.8 (range 2.4-34.7) hr. The cases were divided into 5 groups according to the cold-ischemia time: group 1: < 10 hr (n = 223); group 2: 10-14 hr (n = 188); group 3: 15-19 hr (n = 101); group 4: 20-24 hr (n = 52); and group 5: greater-than-or-equal-to 25 hr (n = 29). There was no difference between the 5 groups in 1-year patient survival, highest SGOT in first week after operation, and SGOT and total bilirubin during the first month after operation. However, with a logistic regression model, the retransplantation rate (P = 0.001) and primary nonfunction rate (P = 0.006) significantly rose as cold-ischemia time increased, meaning that the equivalency of patient survival was increasingly dependent on aggressive retransplantation.