Superior response inhibition to high-calorie foods in adolescents with anorexia nervosa.
Superior response inhibition to high-calorie foods in adolescents with anorexia nervosa.
复制标题
神经性厌食症青少年对高热量食物的卓越反应抑制。
DOI：
10.1016/j.brat.2019.103441
复制
发表时间：
2020
影响因子：
4.1
通讯作者：
Bohon,Cara
中科院分区：
文献类型：
--
作者：
Weinbach,Noam;Lock,James;Bohon,Cara
神经性厌食症（AN）是一种严重的进食障碍，其特征是由于自我饥饿而导致体重显著减轻。人们对这些患者长时间忍受自我饥饿的机制知之甚少。有人认为，负责阻止不适当行为的神经认知机制（即，反应抑制）可能有助于该过程。然而，缺乏支持这一观点的经验证据。本研究的目的是评估与健康青少年相比，接触高热量食物刺激是否会在更大程度上引发AN青少年的反应抑制。30名青少年与限制型AN（AN-R）和30名健康的青少年完成了食物停止信号任务，其中他们的能力，以抑制优势反应进行了评估后，暴露于高热量和低热量的食物图像。结果显示，与对照组相比，患有AN-R的青少年在暴露于高热量食物图像后抑制行动的上级能力。在接触低热量食物的两组之间没有发现这种差异。结果表明，高热量的食物自动触发更强的激活与AN青少年的反应抑制相比，健康的青少年。这种激活可能是AN的独特特征，可能有助于患者严格限制进食的能力。
Anorexia nervosa (AN) is a severe eating disorder that is characterized by significant weight loss as a result of self-starvation. Little is known about the mechanisms that allow these patients to endure self-starvation for long periods of time. It has been suggested that the neurocognitive mechanism responsible for stopping inappropriate actions (i.e., response inhibition) may contribute to this process. However, empirical evidence to support this notion is lacking. The goal of the current study was to assess if exposure to high-calorie food stimuli may trigger response inhibition to a greater extent in adolescents with AN compared to healthy adolescents. Thirty adolescents with restrictive type AN (AN-R) and 30 healthy adolescents completed a food-stop signal task wherein their ability to inhibit prepotent responses was assessed following exposure to high- and low-calorie food images. The results revealed superior ability of adolescents with AN-R to inhibit actions following exposure to high-calorie food images compared with controls. No such difference was found between the groups following exposure to low-calorie foods. The results indicate that high-calorie foods automatically trigger stronger activation of response inhibition in adolescents with AN compared to healthy adolescents. Such activation is likely a unique feature of AN that potentially contributes to patients’ ability to severely restrict eating.