Pim-3 as a potential predictor of chemoradiotherapy resistance in locally advanced rectal cancer patients.
Pim-3 as a potential predictor of chemoradiotherapy resistance in locally advanced rectal cancer patients.
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Pim-3 作为局部晚期直肠癌患者放化疗耐药的潜在预测因子
DOI：
10.1038/s41598-017-16153-3
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发表时间：
2017-11-22
影响因子：
4.6
通讯作者：
Chen G
中科院分区：
文献类型：
--
作者：
Zhang RX;Zhou ZG;Lu SX;Lu ZH;Wan DS;Pan ZZ;Wu XJ;Chen G
Approximately 30% of locally advanced rectal cancer patients might not benefit from chemoradiotherapy; however, the response to neoadjuvant chemoradiotherapy in these cases is difficult to predict. Pim-3 is a member of the provirus integration site for a moloney murine leukemia virus family of proteins that contributes to cell proliferation, survival, and chemotherapy resistance. Therefore, the relationship between Pim-3 expression and response to neoadjuvant chemoradiotherapy in rectal cancer patients is important to evaluate. 175 rectal cancer patients who underwent neoadjuvant treatment enrolled in this study. The relationship between Pim-3 expression on immunohistochemical analysis of rectal cancer tissue, which was obtained before treatment, the response to chemoradiotherapy and survival was investigated. The patients with no Pim-3 expression were more likely to achieve a pathologic complete response to chemoradiotherapy than patients with Pim-3 expression (P = 0.001). Cox multivariate analysis showed that the significant prognostic factors were Pim-3 expression (P = 0.003) and the number of neoadjuvant chemotherapy cycles (P = 0.005) for overall survival. Neoadjuvant chemotherapy cycles (P = 0.007), adjuvant chemotherapy cycles (P = 0.004) and pathology types (P = 0.049) were significant prognostic factors for disease-free survival. Pim-3 is a potential predictive biomarker for the response of rectal cancer to chemoradiotherapy.
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影响因子：
168.9
作者：
Sebag-Montefiore, David;Stephens, Richard J.;Steele, Robert;Monson, John;Grieve, Robert;Khanna, Subhash;Quirke, Phil;Couture, Jean;de Metz, Catherine;Myint, Arthur Sun;Bessell, Eric;Griffiths, Gareth;Thompson, Lindsay C.;Parmar, Mahesh
通讯作者：
Parmar, Mahesh
影响因子：
9.2
作者：
Li Y;Wang J;Ma X;Tan L;Yan Y;Xue C;Hui B;Liu R;Ma H;Ren J
通讯作者：
Ren J
影响因子：
158.5
作者：
Sauer, R;Becker, H;Raab, R
通讯作者：
Raab, R
影响因子：
16
作者：
Ciccia A;Elledge SJ
通讯作者：
Elledge SJ
影响因子：
45.3
作者：
Gerard, Jean-Pierre;Conroy, Thierry;Bedenne, Laurent
通讯作者：
Bedenne, Laurent