Ecology and evolution of rabies virus in Europe
Ecology and evolution of rabies virus in Europe
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DOI：
10.1099/0022-1317-80-10-2545
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发表时间：
1999-10-01
影响因子：
3.8
通讯作者：
Holmes, EC
中科院分区：
文献类型：
--
作者：
Bourhy, H;Kissi, B;Holmes, EC
通过比较核蛋白和糖蛋白基因的核苷酸序列，并使用 RFLP 对分离株进行分型，对主要起源于欧洲的狂犬病病毒的进化进行了研究，对基因序列数据的系统发育分析揭示了许多不同的组，每个组都与特定的地理区域相关。这种模式表明，本世纪狂犬病病毒已在欧洲向西和向南传播，但波兰维斯瓦河等物理屏障促成了局部进化。在这个传播过程中，发生了两种物种的跳跃——一种进入红狐，另一种进入貉，尽管尚不清楚病毒株是否优先适应特定的动物物种，或者生态力量是否解释了系统发育群体的出现。
The evolution of rabies viruses of predominantly European origin was studied by comparing nucleotide sequences of the nucleoprotein and glycoprotein genes, and by typing isolates using RFLP, Phylogenetic analysis of the gene sequence data revealed a number of distinct groups, each associated with a particular geographical area. Such a pattern suggests that rabies virus has spread westwards and southwards across Europe during this century, but that physical barriers such as the Vistula river in Poland have enabled localized evolution. During this dispersal process, two species jumps took place - one into red foxes and another into raccoon dogs, although it is unclear whether virus strains are preferentially adapted to particular animal species or whether ecological forces explain the occurrence of the phylogenetic groups.