An Emerging Role for SNARE Proteins in Dendritic Cell Function.
An Emerging Role for SNARE Proteins in Dendritic Cell Function.
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DOI：
10.3389/fimmu.2015.00133
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发表时间：
2015
影响因子：
7.3
通讯作者：
Loscher CE
中科院分区：
文献类型：
--
作者：
Collins LE;DeCourcey J;Soledad di Luca M;Rochfort KD;Loscher CE
树突状细胞 (DC) 在先天免疫和适应性免疫之间提供了重要的联系。在感染部位，树突状细胞通过模式识别受体（例如 Toll 样受体 (TLR)）识别抗原，启动特异性免疫反应。根据抗原的性质，树突状细胞分泌不同的细胞因子，利用这些细胞因子协调体内平衡和病原体清除。这一过程的失调可能会导致不必要的炎症，进而导致多种炎症性疾病。因此，DC 细胞因子的分泌受到严格调节，并且高度保守的运输蛋白家族促进了这种调节。这些蛋白质控制囊泡从高尔基复合体到细胞表面以及细胞器之间的运输。在这篇综述中，我们将讨论可溶性 n-乙基马来酰亚胺敏感因子附着蛋白受体蛋白 (SNARE) 在 DC 中的作用，它既作为分泌促进剂，又作为通过其在细胞内的确定位置确定分泌途径的有用工具，以及囊泡和靶膜上相对结合配偶体的固有特异性。 SNARE 在 DC 功能中的作用可能为探索这些蛋白质作为炎症疾病的新靶点提供了机会。
Dendritic cells (DCs) provide an essential link between innate and adaptive immunity. At the site of infection, antigens recognized by DCs via pattern-recognition receptors, such as Toll-like receptors (TLRs), initiate a specific immune response. Depending on the nature of the antigen, DCs secrete distinct cytokines with which they orchestrate homeostasis and pathogen clearance. Dysregulation of this process can lead to unnecessary inflammation, which can result in a plethora of inflammatory diseases. Therefore, the secretion of cytokines from DCs is tightly regulated and this regulation is facilitated by highly conserved trafficking protein families. These proteins control the transport of vesicles from the Golgi complex to the cell surface and between organelles. In this review, we will discuss the role of soluble n-ethylmaleimide-sensitive factor attachment protein receptor proteins (SNAREs) in DCs, both as facilitators of secretion and as useful tools to determine the pathways of secretion through their definite locations within the cells and inherent specificity in opposing binding partners on vesicles and target membranes. The role of SNAREs in DC function may present an opportunity to explore these proteins as novel targets in inflammatory disease.
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