Gelatin-Based Photocurable Hydrogels for Corneal Wound Repair
Gelatin-Based Photocurable Hydrogels for Corneal Wound Repair
复制标题
用于角膜伤口修复的明胶光固化水凝胶
DOI：
10.1021/acsami.7b17054
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发表时间：
2018-04-25
影响因子：
9.5
通讯作者：
Hughes, Timothy C.
中科院分区：
文献类型：
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作者：
Li, Lingli;Lu, Conglie;Hughes, Timothy C.
在这项研究中，一种可注射的，光固化明胶系统，由丙烯酸酯明胶和硫醇化明胶，可调的机械，生物降解和生物学特性，被用作一个潜在的细胞支持支架修复局灶性角膜伤口。水凝胶的机械性能可以很容易地修改（固化后的剪切模量为0.3和22 kPa之间），通过改变丙烯酸酯的比例，硫醇基团，光强度，和固体含量，和生物降解时间也随固体含量的变化。更重要的是，所产生的水凝胶在细胞接种和细胞包封实验中均表现出优异的细胞活力。此外，发现水凝胶与兔角膜是生物相容的，并且有助于在局部角膜伤口下的新组织的再生（在局部角膜伤口中表现出上皮伤口覆盖）。
In this study, an injectable, photocurable gelatin system, consisting of acrylated gelatin and thiolated gelatin, with tunable mechanical, biodegradation, and biological properties was used as a potential cell-supportive scaffold for the repair of focal corneal wounds. The mechanical property of hydrogels can be readily modified (postcure shear modulus of between 0.3 and 22 kPa) by varying the ratio of acrylate to thiol groups, photointensity, and solid content, and the biodegradation times also varied with the change of solid content. More importantly, the generated hydrogels exhibited excellent cell viability in both cell seeding and cell encapsulation experiments. Furthermore, the hydrogels were found to be biocompatible with rabbit cornea and aided the regeneration of a new tissue under a focal corneal wound (exhibiting epithelial wound coverage in