Recent progress and open challenges in modeling p53 dynamics in single cells.
Recent progress and open challenges in modeling p53 dynamics in single cells.
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DOI：
10.1016/j.coisb.2017.04.007
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发表时间：
2017-06
影响因子：
3.7
通讯作者：
Loewer A
中科院分区：
文献类型：
--
作者：
Batchelor E;Loewer A
在哺乳动物细胞中，肿瘤抑制因子p53在各种细胞应激时被激活，并确保从停滞和修复到诱导衰老和凋亡的适当反应。在单个活细胞中的定量测量显示，应激诱导后p53积累的刺激依赖性动力学。由于潜在的生化相互作用的复杂性，数学模型对于理解调节p53动力学的网络拓扑结构是必不可少的。最近的工作提供了进一步的见解，在个别细胞的异质性反应的原因，网络的重新布线，以响应不同的输入和下游过程中的作用，在压力下决定细胞的命运。
In mammalian cells, the tumor suppressor p53 is activated upon a variety of cellular stresses and ensures an appropriate response ranging from arrest and repair to the induction of senescence and apoptosis. Quantitative measurements in individual living cells showed stimulus-dependent dynamics of p53 accumulation upon stress induction. Due to the complexity of the underlying biochemical interactions, mathematical models were indispensable for understanding the topology of the network regulating p53 dynamics. Recent work provides furhter insights into the causes of heterogeneous responses in individual cells, the rewiring of the network in response to different inputs and the role of the downstream processes in determining the cellular fate upon stress.