A Computational Model of Degeneracy in a Lymph Node
A Computational Model of Degeneracy in a Lymph Node
复制标题
淋巴结简并性的计算模型
DOI：
10.1007/11823940_13
复制
发表时间：
2006
影响因子：
--
通讯作者：
J. Timmis
中科院分区：
文献类型：
--
作者：
P. Andrews;J. Timmis
本文强调简并性是免疫系统和生物学中的一个重要特性。由此，简并被选为激发人工免疫系统的候选者。作为第一步，在利用退化的力量，我们遵循的概念框架的方法，并建立一个抽象的计算模型，以了解退化检测器的属性没有任何应用偏见。我们建立的模型是基于淋巴结中TH细胞的激活，因为淋巴结是体内对淋巴中外来抗原的适应性免疫反应被激活的部位。该模型包含APC、抗原和TH细胞剂，它们在二维细胞空间中移动和相互作用。假设TH细胞试剂受体是简并的，并测量它们对不同抗原试剂的反应。我们的模型的初步观察和结果，并强调一些退化检测器识别的可能性。
This paper highlights degeneracy as being an important property in both the immune system and biology in general. From this, degeneracy is chosen as a candidate to inspire artificial immune systems. As a first step in exploiting the power of degeneracy, we follow the conceptual framework approach and build an abstract computational model in order to understand the properties of degenerate detectors free of any application bias. The model we build is based on the activation of TH cell in the lymph node, as lymph nodes are the sites in the body where the adaptive immune response to foreign antigen in the lymph are activated. The model contains APC, antigen and TH cell agents that move and interact in a 2-dimensional cellular space. The TH cell agent receptors are assumed to be degenerate and their response to different antigen agents is measured. Initial observations and results of our model are presented and highlight some of the possibilities of degenerate detector recognition.