Natural cytotoxicity receptors that trigger human NK-cell-mediated cytolysis
Natural cytotoxicity receptors that trigger human NK-cell-mediated cytolysis
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DOI：
10.1016/s0167-5699(00)01596-6
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发表时间：
2000-05-01
期刊：
影响因子：
--
通讯作者：
Moretta, L
中科院分区：
文献类型：
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作者：
Moretta, A;Biassoni, R;Moretta, L
自然杀伤(NK)细胞可以检测细胞是否经历了肿瘤转化或病毒感染。主要组织相容性复合体I类分子特异性抑制受体的发现阐明了这种区分的基础。然而，直到最近，在自然细胞毒性过程中负责触发NK细胞的受体仍然是未知的。在这里，亚历山德罗·莫雷塔和他的同事描述了几种这样的受体的鉴定和特征。
Natural killer (NK) cells can detect whether cells have undergone tumor transformation or viral infection. The discovery of specific inhibitory receptors for major histocompatibility complex class I molecules clarified the basis of this discrimination. However, the receptors responsible for NK-cell triggering in the process of natural cytotoxicity remained elusive until recently. Here, Alessandro Moretta and colleagues describe the identification and characterization of several such receptors.