Increased Amplitude of Low-Frequency Fluctuation in Right Angular Gyrus and Left Superior Occipital Gyrus Negatively Correlated With Heroin Use
Increased Amplitude of Low-Frequency Fluctuation in Right Angular Gyrus and Left Superior Occipital Gyrus Negatively Correlated With Heroin Use
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DOI：
10.3389/fpsyt.2020.00492
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发表时间：
2020-07-03
影响因子：
4.7
通讯作者：
Liu, Jun
中科院分区：
文献类型：
--
作者：
Luo, Jing;Yang, Ru;Liu, Jun
低频波动幅度异常与海洛因成瘾有关。然而，之前的研究缺乏一致性，并且没有考虑美沙酮和酒精等混杂因素的影响。 51 名海洛因依赖者 (HD) 和 40 名健康对照者接受了静息态功能磁共振成像。计算“低频波动幅度”（ALFF）值，并应用支持向量机（SVM）分类分析来分析数据。与健康对照组相比，海洛因成瘾者的右角回（AG）和左枕上回（SOG）的 ALFF 增加。右角回和左枕上回ALFF增加与海洛因使用时间呈负相关（p（1）=0.004，r（1）=-0.426；p（2）=0.009，r（2）=-0.361）。此外，右侧 AG 和左侧 SOG 中的 ALFF 可以以可接受的准确度区分 HD 受试者和对照组（Acc(1)=64.85%，p(1)=0.004；Acc(2)=63.80%，p(2)=0.005）。 HD 患者在涉及语义记忆和视觉网络的大脑区域表现出异常的 ALFF。 HD 个体滥用海洛因的时间越长，相关大脑区域的 ALFF 增加就越少。这些观察到的模式表明，海洛因神经毒性的累积效应超过了大脑的自我恢复，并且可以作为潜在的生物标志物来从对照组中识别 HD 个体。
Abnormal amplitude of low-frequency fluctuation has been implicated in heroin addiction. However, previous studies lacked consistency and didn't consider the impact of confounding factors such as methadone and alcohol. Fifty-one heroin-dependent (HD) individuals and 40 healthy controls underwent resting-state functional magnetic resonance imaging. The 'amplitude of low-frequency fluctuation' (ALFF) value was calculated and support vector machine (SVM) classification analysis was applied to analyze the data. Compared with healthy controls, heroin addicts exhibited increased ALFF in the right angular gyrus (AG) and left superior occipital gyrus (SOG). A negative correlation was observed between increased ALFF in the right angular gyrus and left superior occipital gyrus and the duration of heroin use (p(1)=0.004,r(1)=-0.426;p(2)=0.009,r(2)=-0.361). Moreover, the ALFF in the right AG and left SOG could discriminate the HD subjects from the controls with acceptable accuracy (Acc(1)=64.85%,p(1)=0.004; Acc(2)=63.80%,p(2)=0.005). HD patients showed abnormal ALFF in the brain areas involved in semantic memory and visual networks. The longer HD individuals abused heroin, the less the ALFF of associated brain regions increased. These observed patterns suggested that the accumulative effect of heroin's neurotoxicity overpowered self-recovery of the brain and may be applied as a potential biomarker to identify HD individuals from the controls.