Involvement of membranes in cellular responses to hyperthermia.
Involvement of membranes in cellular responses to hyperthermia.
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细胞膜参与细胞对高温的反应。
DOI：
10.2307/3575914
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发表时间：
1982
影响因子：
3.4
通讯作者：
J. Lepock
中科院分区：
文献类型：
--
作者：
J. Lepock
关于细胞膜和暴露在高温下的细胞的活力之间的关系，一些主要的问题仍然没有得到回答。最重要的是，在加热到41-45℃范围内的高温后，膜是否参与了哺乳动物细胞的高温杀戮、辐射增敏或耐热性？如果是，涉及哪些膜：质膜、核膜、线粒体膜、溶酶体膜、内质网状膜等？由于膜的异质性，损伤可能仅限于膜的一个区域(1)。特别是，当膜被加热到高温时，它们会发生哪些特定的分子变化？本文将对加热引起的膜结构和功能的一些已知变化进行总结。
A number of major questions remain unanswered regarding the relationship between cellular membranes and the viability of cells exposed to hyperthermia. Foremost, are membranes involved at all in hyperthermic killing, radiosensitization, or thermotolerance of mammalian cells after heating to hyperthermic temperatures in the range of 41-45?C? If so, which membranes are implicated: plasma, nuclear, mitochondrial, lysosomal, endoplasmic reticular, etc? Damage might be restricted to only one area of a membrane due to membrane heterogeneity (1). In particular, what specific molecular alterations occur in membranes when they are heated to hyperthermic temperatures? In this communication some of the known structural and functional changes in membranes due to heating will be summarized.
高温对表皮生长因子的结合、内化和降解的影响。
影响因子：
3.4
作者：
Magun,BE;Fennie,CW
通讯作者：
Fennie,CW