BIOCHEMICAL AND BEHAVIORAL CHANGES IN RATS EXPOSED TO ETHANOL IN UTERO
BIOCHEMICAL AND BEHAVIORAL CHANGES IN RATS EXPOSED TO ETHANOL IN UTERO
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子宫内暴露于乙醇的大鼠的生化和行为变化
DOI：
10.1111/j.1749-6632.1976.tb52895.x
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发表时间：
1976
影响因子：
5.2
通讯作者：
A. Friedhoff
中科院分区：
文献类型：
--
作者：
L. Branchey;A. Friedhoff
在新生期暴露于各种精神药物的动物中发现了持久的行为和生化改变。某些药物，如安非他明，甲丙氨酯，氯丙嗪或吗啡，给怀孕的动物，已被发现产生持久的变化，在他们的后代。相关文献已由Kornetsky I和Branchey和Friedhoff进行了审查。关于产前接触乙醇的影响知之甚少。在酪氨酸羟化酶（TH），被认为是在儿茶酚胺生物合成的限速酶的变化，发现在这个实验室中暴露于乙醇在uiero的幼鼠的大脑中。i的酶的测定是在8，15岁的幼鼠的尾状核。还有22天。发现TH在所有年龄组中均增加（表I）。大多数研究妊娠期暴露于精神药物的动物后代的实验研究行为或生化变化。为了研究行为和生化参数之间可能的关系，我们研究了开放领域的行为，除了大脑TH，在产前用乙醇处理的幼崽。
Long-lasting behavioral and biochemical modifications have been found in animals exposed to various psychotropic substances during the neonatal period. Certain drugs, such as amphetamine, meprobamate, chlorpromazine, or morphine, administered to pregnant animals have been found to produce enduring changes in their offspring. Pertinent literature has been reviewed by Kornetsky I and Branchey and Friedhoff.? Little is known about the effects of prenatal exposure to ethanol. Changes in tyrosine hydroxylase (TH), believed to be the rate-limiting enzyme in catecholamine biosynthesis, were found in this laboratory in the brains of pups exposed to ethanol in uiero.i The enzyme determinations were made in the caudates of pups aged 8, 15. and 22 days. TH was found to be increased in all age groups (TABLE I ) . Most experiments that study the offspring of animals exposed to psychotropic drugs during the gestational period investigate either behavioral or biochemical changes. To investigate a possible relationship between behavioral and biochemical parameters, we studied open field behavior, in addition to brain TH, in pups treated prenatally with ethanol.