Emerging Diversity of the Cobalamin-Dependent Methyltransferases Involving Radical-Based Mechanisms
Emerging Diversity of the Cobalamin-Dependent Methyltransferases Involving Radical-Based Mechanisms
复制标题
涉及自由基机制的钴胺素依赖性甲基转移酶的新兴多样性
DOI：
10.1002/cbic.201600107
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发表时间：
2016-07-01
期刊：
影响因子：
3.2
通讯作者：
Zhang, Qi
中科院分区：
文献类型：
--
作者：
Ding, Wei;Li, Qien;Zhang, Qi
Cobalamins由一组含钴的有机金属辅因子组成，在细胞代谢中发挥重要作用。虽然许多依赖钴胺的甲基转移酶(如蛋氨酸合成酶甲基)已经被广泛研究，但一类新的依赖钴胺并在催化中利用自由基化学的甲基转移酶才刚刚开始受到重视。在这篇概念性文章中，我们总结了对基于自由基和钴胺依赖的甲基转移酶的理解的最新进展，并讨论了这类新兴酶的功能和机制的多样性。
Cobalamins comprise a group of cobalt-containing organometallic cofactors that play important roles in cellular metabolism. Although many cobalamin-dependent methyltransferases (e.g., methionine synthase MetH) have been extensively studied, a new group of methyltransferases that are cobalamin-dependent and utilize radical chemistry in catalysis is just beginning to be appreciated. In this Concept article, we summarize recent advances in the understanding of the radical-based and cobalamin-dependent methyltransferases and discuss the functional and mechanistic diversity of this emerging class of enzymes.