No evident neuronal damage after electroconvulsive therapy
No evident neuronal damage after electroconvulsive therapy
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电休克治疗后无明显神经元损伤
DOI：
10.1016/s0165-1781(00)00202-x
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发表时间：
2000
影响因子：
11.3
通讯作者：
K. Blennow
中科院分区：
文献类型：
--
作者：
O. Zachrisson;J. Balldin;R. Ekman;O. Naesh;L. Rosengren;H. Ågren;K. Blennow
电休克疗法（ECT）被认为是治疗重度抑郁症最有效的方法之一，但也与可能反映脑损伤的认知缺陷有关。因此，本研究的目的是评估是否ECT诱导脑损伤所反映的不同的生化指标。在9名符合DSM-IV抑郁症标准的患者中测定了脑脊液（CSF）中三种已建立的神经元/神经胶质变性标志物tau蛋白（tau）、神经丝蛋白（NFL）和S-100 β蛋白的浓度。在6次ECT治疗前后采集CSF样本。还在这些时间点测定了反映潜在血脑屏障（BBB）功能障碍的CSF/血清（S）白蛋白比值。治疗在临床上是成功的，通过蒙哥马利-埃斯伯格抑郁评定量表评估，所有患者的抑郁症状显著下降。一些患者在治疗开始前有BBB功能障碍和/或神经元损伤的迹象。ECT对CSF-tau、CSF-NFL和CSF-S-100 β水平无显著影响。此外，发现ECT疗程后CSF/S白蛋白比值无变化。总之，在ECT治疗过程中，没有神经元/神经胶质损伤或BBB功能障碍的生化证据。
Electroconvulsive therapy (ECT) is regarded as one of the most effective treatments for major depressive disorder but has also been associated with cognitive deficits possibly reflecting brain damage. The aim of this study was therefore to evaluate whether ECT induces cerebral damage as reflected by different biochemical measures. The concentrations in the cerebrospinal fluid (CSF) of three established markers of neuronal/glial degeneration, tau protein (tau), neurofilament (NFL) and S-100 beta protein, were determined in nine patients who fulfilled DSM-IV criteria for major depression. CSF samples were collected before and after a course of six ECT sessions. The CSF/serum (S) albumin ratio reflecting potential blood-brain barrier (BBB) dysfunction was also determined at these time points. The treatment was clinically successful with a significant decline of depressive symptoms in all patients as assessed by the Montgomery-Åsberg Rating Scale for Depression. Several patients had signs of BBB dysfunction and/or neuronal damage before the start of treatment. Levels of CSF-tau, CSF-NFL and CSF-S-100 beta levels were not significantly changed by ECT. Also the CSF/S albumin ratio was found to be unchanged after the course of ECT. In conclusion, no biochemical evidence of neuronal/glial damage or BBB dysfunction could be demonstrated following a therapeutic course of ECT.
电休克治疗的脑解剖学影响。
影响因子：
--
作者：
Coffey,CE;Weiner,RD;Djang,WT;Figiel,GS;Soady,SA;Patterson,LJ;Holt,PD;Spritzer,CE;Wilkinson,WE
通讯作者：
Wilkinson,WE
ECT 会改变大脑结构吗？
DOI：
10.1176/ajp.151.7.957
发表时间：
1994
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Devanand,DP;Dwork,AJ;Hutchinson,ER;Bolwig,TG;Sackeim,HA
通讯作者：
Sackeim,HA