The serotonin system in autism
The serotonin system in autism
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DOI：
10.1097/00008480-199608000-00008
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发表时间：
1996-01-01
影响因子：
3.6
通讯作者：
Leventhal, Bennett L.
中科院分区：
文献类型：
--
作者：
Cook, Edwin H., Jr.;Leventhal, Bennett L.
自从1961年发现自闭症患者血液中5-羟色胺(5-羟色胺)水平升高以来，5-羟色胺系统被认为是某些自闭症病例的一个因素。这已经被澄清为血小板中5-羟色胺含量的升高。研究表明，全血5-羟色胺水平升高的受试者血小板5-羟色胺转运增加，5-羟色胺受体结合减少。大多数自闭症患者在接受有效的5-羟色胺转运体抑制剂治疗后，仪式性行为和攻击性都会减少。由急性色氨酸耗竭引起的中枢神经系统5-羟色胺的减少会导致刻板行为的恶化。本文综述了近年来5-羟色胺受体分子生物学的研究进展。
The serotonin system has been implicated as a factor in some cases of autism since the finding in 1961 of elevated serotonin (5-hydroxytryptamine) levels in the blood of patients with autism. This has been clarified as elevation in the platelet content of serotonin. Subjects with elevated whole blood serotonin levels have been shown to have elevated platelet serotonin transport into platelets and decreased serotonin 5-HT 2 receptor binding. Most individuals with autism who are treated with potent serotonin transporter inhibitors have a reduction in ritualistic behavior and aggression. Reduction of central nervous system serotonin, induced by acute tryptophan depletion, causes a worsening of stereotyped behavior. Recent developments in the molecular biology of serotonin receptors are reviewed.