Relationship between serum resistin concentrations and insulin resistance in nonobese, obese, and obese diabetic subjects
Relationship between serum resistin concentrations and insulin resistance in nonobese, obese, and obese diabetic subjects
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DOI：
10.1210/jc.2003-031410
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发表时间：
2004-04-01
影响因子：
5.8
通讯作者：
Smith, SR
中科院分区：
文献类型：
--
作者：
Heilbronn, LK;Rood, J;Smith, SR
早期的报告表明，抵抗素与啮齿动物的肥胖和胰岛素抵抗有关。然而，随后的研究并没有支持这些发现。据我们所知，本研究是第一次用胰岛素钳技术评估人类受试者的血清抵抗素和胰岛素敏感性。38例非肥胖受试者[年龄，23±4岁；体重指数（BMI）为25.4 +/- 4.3 kg/m(2)，肥胖受试者12例（年龄54 +/- 8岁，BMI为33.0 +/- 2.5 kg/m(2)），肥胖合并2型糖尿病受试者22例（年龄59 +/- 7岁，BMI为34.0 +/- 2.4 kg/m(2)）。血清抵抗素浓度在非肥胖者（4.1 +/- 1.7 ng/ml）、肥胖者（4.2 +/- 1.6 ng/ml）和肥胖糖尿病患者（3.7 +/- 1.2 ng/ml）之间无显著差异，且与各组高胰岛素血糖钳夹期间的葡萄糖处置率无显著相关。然而，血清抵抗素仅在非肥胖受试者中与胰岛素敏感性呈负相关（r = -0.35; P = 0.05），尽管在调整体脂百分比后这种关联消失。血清抵抗素与脂肪百分比、BMI或脂肪细胞大小无关。在另一组肥胖受试者中，血清抵抗素与腹部脂肪组织中抵抗素mRNA的表达有很强的相关性（r = 0.62; P < 0.01; n = 56）。尽管抵抗素的确切功能尚不清楚，但在非肥胖受试者中，我们只证明了抵抗素和胰岛素敏感性之间的微弱关系，这表明抵抗素不太可能是人类肥胖和胰岛素抵抗之间的主要联系。
Early reports suggested that resistin is associated with obesity and insulin resistance in rodents. However, subsequent studies have not supported these findings. To our knowledge, the present study is the first assessment in human subjects of serum resistin and insulin sensitivity by the insulin clamp technique. Thirty-eight nonobese subjects [age, 23 +/- 4 yr; body mass index (BMI), 25.4 +/- 4.3 kg/m(2)], 12 obese subjects (age, 54 +/- 8 yr; BMI, 33.0 +/- 2.5 kg/m(2)), and 22 obese subjects with type 2 diabetes (age, 59 +/- 7 yr; BMI, 34.0 +/- 2.4 kg/m(2)) were studied. Serum resistin concentrations were not different among nonobese (4.1 +/- 1.7 ng/ml), obese (4.2 +/- 1.6 ng/ml), and obese diabetic subjects (3.7 +/- 1.2 ng/ml), and were not significantly correlated to glucose disposal rate during a hyperinsulinemic glucose clamp across groups. Serum resistin was, however, inversely related to insulin sensitivity in nonobese subjects only (r = -0.35; P = 0.05), although this association was lost after adjusting for percent body fat. Serum resistin was not related to percent fat, BMI, or fat cell size. A strong correlation was observed between serum resistin and resistin mRNA expression from abdominal sc adipose tissue in a separate group of obese subjects (r = 0.62; P < 0.01; n = 56). Although the exact function of resistin is unknown, we demonstrated only a weak relationship between resistin and insulin sensitivity in nonobese subjects, indicating that resistin is unlikely to be a major link between obesity and insulin resistance in humans.