Event-related potentials in schizophrenia during tonal and phonetic oddball tasks: Relations to diagnostic subtype, symptom features and verbal memory
Event-related potentials in schizophrenia during tonal and phonetic oddball tasks: Relations to diagnostic subtype, symptom features and verbal memory
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DOI：
10.1016/s0006-3223(01)01168-4
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发表时间：
2001-09-15
影响因子：
10.6
通讯作者：
Gorman, JM
中科院分区：
文献类型：
--
作者：
Bruder, GE;Kayser, J;Gorman, JM
背景资料：本研究，比较事件相关电位偏执患者（n = 13）与匹配的未分化患者和未用药患者（n = 14）与匹配的健康，adults.Methods：事件相关电位的右利手患者和对照组被记录在30个电极在古怪的任务，使用辅音-元音音节或复杂的音调。患者也进行了评估，使用阳性和阴性症状量表，思维障碍指数，和韦氏记忆Scale.Results：偏执患者没有不同的未分化患者的N1或P3振幅，但表现出较大的N2在额中央部位的语音刺激，以及较大的N2在左半球比右半球。未用药的患者表现出减少N2，但不是N1或P3，相比对照subjects.Conclusions：N2的研究结果是一致的神经心理学证据更大的语言能力和左半球的优势，偏执型精神分裂症比非偏执型。研究结果还证实了P3与简明精神病评定量表总分、阴性症状和言语联想记忆的关系。生物精神病学2001;50：447-452（C）2001年社会，生物精神病学。
Background: This study, compares event-related potentials for paranoid patients (n = 13) versus matched undifferentiated patients and unmedicated patients (n = 14) versus matched healthy, adults.Methods: Event-related potentials of right-handed patients and control subjects were recorded from 30 electrodes during oddball tasks using consonant-vowel syllables or complex tones. Patients were also assessed using the Positive and Negative Syndrome Scale, the Thought Disorder Index, and the Wechsler Memory Scale.Results: Paranoid patients did not differ from undifferentiated patients in N1 or P3 amplitude but showed larger N2 at frontocentral sites to phonetic stimuli, as well as larger N2 over left than right hemisphere. Unmedicated patients showed reduced N2, but not N1 or P3, compared to control subjects.Conclusions: The N2 findings are consistent with neuropsychological evidence of greater verbal abilities and left hemisphere dominance in paranoid than nonparanoid schizophrenia. The findings also confirm the relationship of P3 to total Brief Psychiatric Rating Scale score, negative symptoms, and verbal associative memory. Biol Psychiatry 2001;50:447-452 (C) 2001 Society, of Biological Psychiatry.