PLANT ANTICANCER AGENTS-XLIV - CYTOTOXIC CONSTITUENTS FROM STIZOPHYLLUM-RIPARIUM
PLANT ANTICANCER AGENTS-XLIV - CYTOTOXIC CONSTITUENTS FROM STIZOPHYLLUM-RIPARIUM
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DOI：
10.1021/np50049a010
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发表时间：
1987-01-01
影响因子：
5.1
通讯作者：
FARNSWORTH, NR
中科院分区：
文献类型：
--
作者：
DUH, CY;PEZZUTO, JM;FARNSWORTH, NR
生物活性导向的分离Stizophyllum riparium的CHCl 3提取物得到了六种新化合物，即三萜酯、3 β-羟基-24-反式-阿魏酰氧基乌苏-12-烯-28-酸[1]，3 β-羟基-24-顺式-阿魏酰氧基乌苏-12-烯-28-酸[2] 3 β-，19-二羟基-24-反式-阿魏酰氧基乌苏-12-烯-28-酸[3]，和藜芦烷衍生物，2 α，3 β，12. β-三羟基孕甾-4，7，16-三烯-20-酮[4]，2 α，3 β，12. β-三羟基孕甾-4，7-二烯-20-酮[5]和16 α-甲氧基-2 α，3 β，12. β-三羟基孕甾-4，7-二烯-20-酮[6]。通过光谱和化学方法确定了这些分离物的结构。化合物1、2和4在细胞培养物中对P-388淋巴细胞白血病试验系统显示出细胞毒活性。
Bioactivity-guided fractionation of a CHCl3 extract of Stizophyllum riparium has afforded six new compounds, namely, the triterpene esters, 3.beta.-hydroxy-24-trans-ferulyloxyurs-12-en-28-oic acid [1], 3.beta.-hydroxy-24-cis-ferulyloxyurs-12-en-28-oic acid [2] 3.beta.-,19-dihydroxy-24-trans-ferulyloxyurs-12-en-28-oic acid [3], and the pregnane derivatives, 2.alpha.,3.beta.,12.beta.-trihydroxypregna-4,7,16-trien-20-one [4], 2.alpha.,3.beta.,12.beta.-trihydoxypregna-4,7-dien-20-one [5] and 16.alpha.-methoxy-2.alpha.,3.beta.,12.beta.-trihydroxypregna-4,7-dien-20-one [6]. The structures of these isolates were established by spectroscopic and chemical methods. Compounds 1, 2, and 4 exhibited cytotoxic activity against the P-388 lymphocytic leukemia test system in cell culture.