HALOTHANE, ISOFLURANE, AND ENFLURANE MAC IN PREGNANT AND NONPREGNANT FEMALE AND MALE-MICE AND RATS
HALOTHANE, ISOFLURANE, AND ENFLURANE MAC IN PREGNANT AND NONPREGNANT FEMALE AND MALE-MICE AND RATS
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DOI：
10.1097/00000542-198503000-00021
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发表时间：
1985-01-01
期刊：
影响因子：
8.8
通讯作者：
BADEN, JM
中科院分区：
文献类型：
--
作者：
MAZZE, RI;RICE, SA;BADEN, JM
在妊娠雌性、非妊娠雌性和雄性Swiss韦伯斯特小鼠（n = 216）和Sprague-Dawley大鼠（n = 112）中，采用尾部钳夹技术测定氟烷、异氟烷和恩氟烷的MAC [最小肺泡浓度]。平均MAC值（±. SD）为0.95 ± 0.95。0.07%，1.34 ±。0.10%和1.95 ±。0.16%;大鼠中的值为1.03 . ±. 0.04%，1.46 ±。0.06%和2.21 ±。0.08%，均显著高于小鼠。 动物的性别和雌性动物是否妊娠均不影响结果。
The MAC [minimum alveolar concentration] of halothane, isoflurane and enflurane was determined using the tail-clamp technique in pregnant female, nonpregnant female and male Swiss Webster mice (n = 216) and Sprague-Dawley rats (n = 112). Mean MAC values (.+-. SD) for halothane, isoflurane and enflurane in mice were 0.95 .+-. 0.07%, 1.34 .+-. 0.10% and 1.95 .+-. 0.16%, respectively; values in rats were 1.03 .+-. 0.04%, 1.46 .+-. 0.06% and 2.21 .+-. 0.08%, respectively, all significantly higher than in mice. Neither the sex of the animals nor whether female animals were pregnant influenced the results.