B-cell maturation protein, which binds the tumor necrosis factor family members BAFF and APRIL, is dispensable for humoral immune responses
B-cell maturation protein, which binds the tumor necrosis factor family members BAFF and APRIL, is dispensable for humoral immune responses
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DOI：
10.1128/mcb.21.12.4067-4074.2001
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发表时间：
2001-06-01
影响因子：
5.3
通讯作者：
Lam, KP
中科院分区：
文献类型：
--
作者：
Xu, SL;Lam, KP
B细胞成熟蛋白（BCMA）是肿瘤坏死因子（TNF）受体家族的成员，在B淋巴细胞中表达。BCMA结合两个TNF家族成员BAFF和APRIL，刺激细胞增殖。RAFF特别地已经显示影响B细胞存活和活化，并且过表达BAFF的转基因小鼠具有狼疮样自身免疫性疾病。我们已经在小鼠生殖系中灭活了BCMA。BCMA（-/-）小鼠具有正常的B细胞发育，并且突变型B淋巴细胞的寿命与野生型B细胞的寿命相当。BCMA（-/-）小鼠对T细胞非依赖性抗原以及高剂量和低剂量的T细胞依赖性抗原的体液免疫应答也是完整的。此外，突变小鼠具有正常的脾脏结构，并且在持续的免疫应答期间形成生发中心。这些数据表明BCMA在B细胞生理学中的功能冗余，这可能是由于TACI的存在，TACI是在B细胞上表达的另一种TNF受体家族成员，也可以结合BAFF和APRIL。
B cell maturation protein (BCMA) is a member of the tumor necrosis factor (TNF) receptor family and is expressed in B lymphocytes. BCMA binds two TNF family members, BAFF and APRIL, that stimulate cellular proliferation. RAFF in particular has been shown to influence B-cell survival and activation, and transgenic mice overexpressing BAFF have a lupus like autoimmune disorder. We have inactivated BCMA in the mouse germ line. BCMA(-/-) mice have normal B-cell development, and the life span of mutant B lymphocytes is comparable to that of wild-type B cells. The humoral immune responses of BCMA(-/-) mice to T-cell-independent antigens as well as high and low doses of T-cell-dependent antigens are also intact. In addition, mutant mice have normal splenic architecture, and germinal centers are formed during an ongoing immune response. These data suggest a functional redundancy of BCMA in B-cell physiology that is probably due to the presence of TACI, another TNF receptor family member that is expressed on B cells and that can also bind BAFF and APRIL.