Assessment of coronary arterial plaque by optical coherence tomography
Assessment of coronary arterial plaque by optical coherence tomography
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DOI：
10.1016/j.amjcard.2005.11.035
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发表时间：
2006-04-15
影响因子：
2.8
通讯作者：
Yoshida, K
中科院分区：
文献类型：
--
作者：
Kume, T;Akasaka, T;Yoshida, K
本研究的目的是分析光学相干断层扫描（OCT）识别经组织学检查诊断的冠状动脉斑块的能力。我们从连续40具人类尸体（24名男性和16名女性，平均年龄74±7岁）的108个冠状动脉段中提取了166个切片。斑块类型分为纤维性斑块（n = 43）、纤维钙化斑块（n = 82）和富含脂质斑块（n = 41）。研究了OCT和血管内超声（IVUS）表征斑块类型的准确性，以组织学一致诊断为金标准。OCT和IVUS对不同类型的动脉粥样硬化斑块具有很高的敏感性和特异性。OCT对富脂斑块的敏感性高于IVUS （85% vs 59%, p = 0.03）。总之，OCT的高分辨率使得富脂斑块的评估比IVUS更准确。(c) 2006爱思唯尔公司版权所有。
The purpose of this study was to analyze the ability of optical coherence tomography (OCT) to identify coronary arterial plaque diagnosed by histologic examination. We examined 166 sections from 108 coronary arterial segments of 40 consecutive human cadavers (24 men and 16 women; mean age 74 +/- 7 years). The plaque type was classified as fibrous (n = 43), fibrocalcific (n = 82), or lipid-rich (n = 41). The accuracy of OCT and intravascular ultrasound (IVUS) in characterizing the plaque type was studied, with the histologic consensus diagnosis serving as the gold standard. OCT, as well as IVUS, had high sensitivity and specificity for characterizing the different types of atherosclerotic plaque. OCT had a higher sensitivity for characterizing lipid-rich plaques than IVUS (85% vs 59%, p = 0.03). In conclusion, the high resolution of OCT permitted evaluation of lipid-rich plaques more accurately than IVUS. (c) 2006 Elsevier Inc. All rights reserved.