Midkine expression is correlated with an adverse prognosis and is down-regulated by p53 in oral squamous cell carcinoma
Midkine expression is correlated with an adverse prognosis and is down-regulated by p53 in oral squamous cell carcinoma
复制标题
DOI：
10.3892/ijo_00000729
复制
发表时间：
2010-10-01
影响因子：
5.2
通讯作者：
Ando, Yukio
中科院分区：
文献类型：
--
作者：
Ota, Kazutoshi;Fujimori, Hiromi;Ando, Yukio
中期因子（MK）的表达已被证明与各种肿瘤患者的预后呈负相关，但这种关系的机制尚未得到很好的表征。最近的研究还将p53表达与口腔鳞状细胞癌（OSCC）患者的预后相关。我们评估MK表达与OSCC患者临床病理特征之间的关系，以阐明p53状态对OSCC细胞MK表达的影响。我们的研究结果表明，MK过度表达的OSCC患者的5年生存率明显低于MK低表达的患者。免疫组化分析表明MK蛋白在突变型p53的口腔鳞癌标本中过度表达。人舌鳞癌细胞培养实验表明MK基因受野生型p53基因调控。因此，MK表达可能通过p53状态和p53基因突变影响预后，MK可能是具有突变型p53的癌细胞患者的治疗干预的有吸引力的靶点。
Midkine (MK) expression has been documented to be inversely correlated with the prognosis of patients with various tumors, but the mechanism of this relationship has not been well characterized. Recent studies have also correlated p53 expression with prognosis of patients with oral squamous cell carcinoma (OSCC). We evaluated the relationship between MK expression and clinicopathological features of patients with OSCC to clarify the influence of p53 status on MK expression in OSCC cells. Our results showed that patients with MK over-expression in OSCC cells had a significantly lower 5-year survival rate compared with patients with low MK expression. Immunohistochemical analyses demonstrated overexpression of MK protein in OSCC samples with mutant p53. Cell culture experiments with human lingual squamous cell carcinoma revealed that the MK gene was regulated by the wild-type p53 gene. Thus, MK expression may affect prognosis via the p53 status and mutation of the p53 gene, and MK may be an attractive target for therapeutic intervention in patients with cancer cells with mutant p53.