The Complex Integration of T-cell Metabolism and Immunotherapy.
The Complex Integration of T-cell Metabolism and Immunotherapy.
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DOI：
10.1158/2159-8290.cd-20-0569
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发表时间：
2021-07
期刊：
影响因子：
28.2
通讯作者：
Rathmell JC
中科院分区：
文献类型：
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作者：
Madden MZ;Rathmell JC
过继性细胞治疗和免疫检查点阻断的免疫肿瘤学方法旨在激活T细胞以消除肿瘤。静息T细胞的正常刺激诱导代谢重编程，从分解代谢和氧化代谢到效应T细胞中的有氧糖酵解，并回到长寿记忆细胞中的氧化代谢。这些代谢重编程事件现在被认为是T细胞功能和命运的重要方面。在这里，我们回顾这些转变，它们如何被T细胞与肿瘤和肿瘤微环境的相互作用破坏，以及它们如何为免疫肿瘤学提供信息，以增强T细胞对肿瘤的功能。
Immune oncology approaches of adoptive cell therapy and immune checkpoint blockade aim to activate T cells to eliminate tumors. Normal stimulation of resting T cells induces metabolic reprogramming from catabolic and oxidative metabolism to aerobic glycolysis in effector T cells, and back to oxidative metabolism in long-lived memory cells. These metabolic reprogramming events are now appreciated to be essential aspects of T cell function and fate. Here we review these transitions, how they are disrupted by T cell interactions with tumors and the tumor microenvironment, and how they can inform immune oncology to enhance T cell function against tumors.