An Efficient Transformation from Benzyl or Allyl Halides to Aryl and Alkenyl Nitriles
An Efficient Transformation from Benzyl or Allyl Halides to Aryl and Alkenyl Nitriles
复制标题
从苄基或烯丙基卤化物到芳基和烯基腈的有效转化
DOI：
10.1021/ol101094u
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发表时间：
2010-06-18
期刊：
影响因子：
5.2
通讯作者：
Jiao, Ning
中科院分区：
文献类型：
--
作者：
Zhou, Wang;Xu, Jiaojiao;Jiao, Ning
开发了一种由苄基和烯丙基卤制备芳基或烯基腈的新方法。一个串联的TBAB催化的取代和随后的新的氧化重排参与这一转变。据我们所知，这是从烯丙基卤到烯基腈的第一次转化。这些方法反应范围广，反应条件温和，可用于有机合成。
A novel approach to aryl or alkenyl nitriles from benzyl and allyl halides has been developed. A tandem TBAB-catalyzed substitution and the subsequent novel oxidative rearrangement are involved in this transformation. To the best of our knowledge, this is the first transformation from allyl halides to alkenyl nitriles. The broad reaction scope and the mild conditions may make these methods of use in organic synthesis.