An integrated view of cisplatin-induced nephrotoxicity and ototoxicity.
An integrated view of cisplatin-induced nephrotoxicity and ototoxicity.
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DOI：
10.1016/j.toxlet.2015.06.012
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发表时间：
2015-09-17
影响因子：
3.5
通讯作者：
Steyger PS
中科院分区：
文献类型：
--
作者：
Karasawa T;Steyger PS
顺铂是治疗癌症最广泛使用的药物之一。然而，其肾毒性和耳毒性的副作用仍然是主要的临床限制。最近的研究提高了我们对顺铂诱导肾毒性和耳毒性的分子机制的理解。虽然顺铂与DNA结合是增殖（癌症）细胞的主要细胞毒性机制，但肾毒性和耳毒性似乎是由各种细胞区室中活性氧的毒性水平和蛋白质失调引起的。本文就顺铂所致肾毒性和耳毒性的分子机制作一综述。我们还讨论了预防肾毒性和耳毒性的潜在临床策略及其目前的局限性。
Cisplatin is one of the most widely-used drugs to treat cancers. However, its nephrotoxic and ototoxic side-effects remain major clinical limitations. Recent studies have improved our understanding of the molecular mechanisms of cisplatin-induced nephrotoxicity and ototoxicity. While cisplatin binding to DNA is the major cytotoxic mechanism in proliferating (cancer) cells, nephrotoxicity and ototoxicity appear to result from toxic levels of reactive oxygen species and protein dysregulation within various cellular compartments. In this review, we discuss molecular mechanisms of cisplatin-induced nephrotoxicity and ototoxicity. We also discuss potential clinical strategies to prevent nephrotoxicity and ototoxicity and their current limitations.