CYP1B1 and CYP19 gene polymorphisms and breast cancer incidence: no association in the ARIC study.
CYP1B1 and CYP19 gene polymorphisms and breast cancer incidence: no association in the ARIC study.
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CYP1B1 和 CYP19 基因多态性与乳腺癌发病率：ARIC 研究中没有关联。
DOI：
10.1016/j.canlet.2003.12.009
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发表时间：
2004
期刊：
影响因子：
9.7
通讯作者：
Gross,Myron
中科院分区：
文献类型：
--
作者：
Thyagarajan,Bharat;Brott,Marcia;Mink,Pamela;Folsom,AaronR;Anderson,KristinE;Oetting,WilliamStarr;Gross,Myron
我们在社区动脉粥样硬化风险研究中对178例乳腺癌病例和356例对照进行了巢式病例对照研究。我们评估了乳腺癌与CYP 1B 1基因Val 432 Leu多态性和CYP 19基因内含子4中的四核苷酸重复序列之间的关联。校正身高、绝经年龄、初潮年龄、BMI、HRT和酒精摄入量后，瓦尔/Leu或瓦尔/瓦尔基因型携带者患乳腺癌的几率是Leu/Leu携带者的1.45倍（95%CI 0.85-2.47）。乳腺癌与任何单个CYP 19等位基因均无关联。与167等位基因纯合子个体相比，167杂合子基因型和其余四核苷酸重复组合的优势比接近1.0。我们的数据显示，乳腺癌和CYP 1B 1基因的Leu 432 Val多态性或CYP 19基因的四核苷酸重复之间没有关联。
We conducted a nested case control study of 178 incident breast cancer cases and 356 controls in the Atherosclerosis Risk in Communities study. We evaluated the association between breast cancer and Val432Leu polymorphism in the CYP1B1 gene and the tetranucleotide repeats in intron 4 of the CYP19 gene. After adjustment for height, age at menopause, age at menarche, BMI, HRT, and alcohol intake, carriers of the Val/Leu or Val/Val genotype had a 1.45 fold (95% CI 0.85–2.47) greater odds of breast cancer than Leu/Leu carriers. There was no association of the breast cancer with any individual CYP19 allele. Compared to individuals homozygous with the 167 allele, odds ratios were close to 1.0 for the 167 heterozygous genotype and for the remaining tetranucleotide repeats combined. Our data shows no association between breast cancer and the Leu432Val polymorphism of the CYP1B1 gene or the tetranucleotide repeats of the CYP19 gene.