Structural variation of the monoamine oxidase A gene promoter repeat polymorphism in nonhuman primates.
Structural variation of the monoamine oxidase A gene promoter repeat polymorphism in nonhuman primates.
复制标题
非人灵长类动物中单胺氧化酶 A 基因启动子重复多态性的结构变异。
DOI：
10.1111/j.1601-183x.2005.00130.x
复制
发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Lesch,KP
中科院分区：
文献类型：
--
作者：
Wendland,JR;Hampe,M;Newman,TK;Syagailo,Y;Meyer,J;Schempp,W;Timme,A;Suomi,SJ;Lesch,KP
通过赋予人类单胺氧化酶A（MAOA）基因等位基因特异性转录活性，MAOA启动子中重复序列[（可变串联重复序列（VNTR））]的长度变化影响了与攻击性和反社会行为相关的一系列人格特征，并增加了神经发育和精神疾病的风险。在这里，我们分析了MAOA启动子重复序列在几种非人灵长类动物中的存在和变异性。MAOA转录控制区的序列分析揭示了VNTR在黑猩猩（Pan troglodytes）、倭黑猩猩（Pan paniscus）、大猩猩（Gorilla gorilla）、猩猩（Pongo pygmaeus）、恒河猴（Macaca mulatta）和狒狒（Theropithecus gelada）中的存在。大多数P。穴居人和P. paniscus显示了一个单一的重复序列，其序列与人类的VNTR序列相同。相反，对其余物种的分析揭示了类似于人VNTR的前18 bp的较短序列。 与其它非人灵长类动物相比，M. mulatt显示了最高的长度变异与等位基因频率为35，25和40%，分别为5，6和7个重复变异。恒河猴和人类中MAOA启动子重复序列的变异程度支持了人类和恒河猴群体中功能性MAOA表达与攻击相关性状之间可能存在关系的观点。
By conferring allele‐specific transcriptional activity on themonoamine oxidase A(MAOA) gene in humans, length variation of a repetitive sequence [(variable number of tandem repeat (VNTR)] in theMAOApromoter influences a constellation of personality traits related to aggressive and antisocial behavior and increases the risk of neurodevelopmental and psychiatric disorders. Here, we have analyzed the presence and variability of thisMAOApromoter repeat in several species of nonhuman primates. Sequence analysis ofMAOA's transcriptional control region revealed the presence of the VNTR in chimpanzee (Pan troglodytes), bonobo (Pan paniscus), gorilla (Gorilla gorilla), orangutan (Pongo pygmaeus), rhesus macaque (Macaca mulatta) and Gelada baboon (Theropithecus gelada). The majority ofP. troglodytesandP. paniscusshowed a single repeat with a sequence identical to the VNTR sequence in humans. In contrast, analyses of the remaining species revealed shorter sequences similar to the first 18 bp of human VNTR. Compared with other nonhuman primates, the VNTR sequence ofM. mulattashowed the highest length variability with allele frequencies of 35, 25 and 40% for the five, six and seven repeat variants, respectively. The extent of variability of theMAOApromoter repeat in both rhesus monkeys and humans supports the notion that there may be a relationship between functional MAOA expression and aggression‐related traits in humans and rhesus macaque populations.