Quality of life and calcium channel blockade with nifedipine GITS versus amlodipine in hypertensive patients in Spain. Gastrointestinal Therapeutic System.
Quality of life and calcium channel blockade with nifedipine GITS versus amlodipine in hypertensive patients in Spain. Gastrointestinal Therapeutic System.
复制标题
西班牙高血压患者中硝苯地平 GITS 与氨氯地平的生活质量和钙通道阻滞作用。
DOI：
10.1097/00004872-199816120-00018
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发表时间：
1998
影响因子：
4.9
通讯作者：
Luque-Otero,M
中科院分区：
文献类型：
--
作者：
Testa,MA;Turner,RR;Simonson,DC;Krafcik,MB;Calvo,C;Luque-Otero,M
高血压治疗依从性受影响生活质量的治疗相关因素(复杂性、副作用)、疗效和化合物特异性效应的影响。这项研究考察了两种每日服用一次的钙通道阻滞剂使用不同的给药系统：硝苯地平胃肠治疗系统(GITS)和氨氯地平的生活质量的差异。设计：这是一项双盲、双模拟、随机临床试验，比较了硝苯地平控释片(30 Mg)和氨氯地平(5 Mg)在安慰剂磨合后24周的疗效。临床、实验室评估和生活质量数据在筛查、基线随机化和积极治疗期间三次进行评估。
ObjectiveCompliance with hypertension treatment is affected by treatment-related factors (complexity, side effects), efficacy and compound-specific effects that impact on quality of life. This study examined the differences in quality of life produced by two once-daily calcium channel blockers using different delivery systems: nifedipine gastrointestinal therapeutic system (GITS) and amlodipine.DesignThis was a double-blind, double-dummy, randomized clinical trial comparing nifedipine GITS (30 mg) and amlodipine (5 mg) for 24 weeks following a placebo run-in. Clinical, laboratory evaluations and quality-of-life data were assessed at screening, baseline randomization and three times during active therapy.Setting