Bright spots: correlations of gray matter volume with IQ in a normal pediatric population
Bright spots: correlations of gray matter volume with IQ in a normal pediatric population
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DOI：
10.1016/s1053-8119(03)00199-x
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发表时间：
2003-09-01
期刊：
影响因子：
5.7
通讯作者：
Holland, SK
中科院分区：
文献类型：
--
作者：
Wilke, M;Sohn, JH;Holland, SK
儿童中与认知功能相关的大脑区域的定位尚未得到彻底探索。因此，我们着手将体积、基于体素和结构连接分析应用于大量健康儿童样本的磁共振图像。我们可以证实全脑灰质体积与个体智商之间存在很强的相关性；然而，在我们的样本中，这种相关性仅随着年龄的增长而发展，因为它在年幼的儿童中不存在。通过应用基于体素的形态测量的优化方案，前扣带回被证明与人类智力的测量直接相关。此外，对结构连接性的分析发现几个不同大脑区域的灰质体积与认知功能相关。我们讨论了我们的发现对正常发育、病理过程和我们对认知的理解的影响，并与之前的发现相关。 (C) 2003 年爱思唯尔科学（美国）。版权所有。
The localization of brain areas related to cognitive functions has yet to be thoroughly explored in children. We therefore set out to apply volumetric, voxel-based, and structural connectivity analyses to magnetic resonance images from a large sample of healthy children. We could confirm a strong correlation of whole-brain gray matter volume and the individual intelligence quotient; however, this correlation only developed with age in our sample, in that it was not present in the younger children. With the application of an optimized protocol for voxel-based morphometry, the anterior cingulate was shown to be directly correlated with a measure of human intelligence. Furthermore, an analysis of structural connectivity identified gray matter volume in several distinct brain areas to be related to cognitive functions. The implications of our findings for normal development, pathological processes, and our understanding of cognition are discussed and related to previous findings. (C) 2003 Elsevier Science (USA). All rights reserved.