Rational Design of Meso-Phosphino-Substituted BODIPY Probes for Imaging Hypochlorite in Living Cells and Mice
Rational Design of Meso-Phosphino-Substituted BODIPY Probes for Imaging Hypochlorite in Living Cells and Mice
复制标题
用于活细胞和小鼠次氯酸盐成像的内消旋膦取代 BODIPY 探针的合理设计
DOI：
10.1021/acs.analchem.1c02025
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发表时间：
2021-07-01
影响因子：
7.4
通讯作者：
Yoon, Juyoung
中科院分区：
文献类型：
--
作者：
Ma, Chunyu;Hou, Shumin;Yoon, Juyoung
为了简便、快速地检测次氯酸盐（ClO-），开发了一种新型的内位膦基取代的BODIPY探针。有趣的是，探针BP通过关闭光诱导电子转移（PET）效应和扩展共面共轭π系统给出了开启荧光响应。相反，探针TMBP显示出对ClO-的比色响应。空间排斥的关键作用被揭示为改变BODIPY核心的电子分布，导致这些明显不同的响应。最后，探针BP对ClO-具有高选择性和灵敏度（LOD = 1.9 nM;响应时间，
Meso-phosphino-substituted BODIPY probes were developed for concise and rapid detection of hypochlorite (ClO-). Interestingly, the probe BP gave a turn-on fluorescence response by shutting the photoinduced electron transfer (PET) effect and extending the coplanar conjugated pi-system. In contrast, the probe TMBP showed a colorimetric response toward ClO-. The key role of the steric repulsions was revealed to be for altering the electronic distribution of the BODIPY core, resulting in these obviously different responses. Finally, the probe BP, with high selectivity and sensitivity toward ClO- (LOD = 1.9 nM; response time,