A prototype portable breath acetone analyzer for monitoring fat loss
A prototype portable breath acetone analyzer for monitoring fat loss
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DOI：
10.1088/1752-7155/7/3/036005
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发表时间：
2013-09-01
影响因子：
3.8
通讯作者：
Yamada, Yuki
中科院分区：
文献类型：
--
作者：
Toyooka, Tsuguyoshi;Hiyama, Satoshi;Yamada, Yuki
呼气中含有的丙酮是体内脂肪分解的代谢产物，有望成为脂肪燃烧的良好指标。通常情况下，人们使用气相色谱或质谱仪来测量呼气中的低浓度化合物，但这样的大型仪器不适合有饮食意识的人日常使用。在这里，我们制作了便携式呼气丙酮分析仪的原型，该分析仪具有两种不同灵敏度特性的基于半导体的气体传感器，能够在计算丙酮浓度的同时考虑乙醇、氢和湿度的存在。为了研究我们的原型的准确性及其在饮食支持中的应用，我们在健康的成年志愿者上进行了实验。从我们的原型和气相色谱中获得的呼气丙酮浓度在整个实验过程中显示出很强的相关性。此外，控制卡路里摄入量和锻炼的受试者体内脂肪显著减少，而这些受试者的呼气丙酮浓度显著增加。这些结果证明了我们的样机对于家庭和室外脂肪燃烧的自我监测是实用的和有用的。我们的原型将有助于预防和缓解肥胖和糖尿病。
Acetone contained in our exhaled breath is a metabolic product of the breakdown of body fat and is expected to be a good indicator of fat-burning. Typically, gas chromatography or mass spectrometry are used to measure low-concentration compounds in breath but such large instruments are not suitable for daily use by diet-conscious people. Here, we prototype a portable breath acetone analyzer that has two types of semiconductor-based gas sensors with different sensitivity characteristics, enabling the acetone concentration to be calculated while taking into account the presence of ethanol, hydrogen, and humidity. To investigate the accuracy of our prototype and its application in diet support, experiments were conducted on healthy adult volunteers. Breath acetone concentrations obtained from our prototype and from gas chromatography showed a strong correlation throughout the experiments. Moreover, body fat in subjects with a controlled caloric intake and taking exercise decreased significantly, whereas breath acetone concentrations in those subjects increased significantly. These results prove that our prototype is practical and useful for self-monitoring of fat-burning at home or outside. Our prototype will help to prevent and alleviate obesity and diabetes.