INDUCTION OF AN OLFACTORY MEMORY BY THE ACTIVATION OF A METABOTROPIC GLUTAMATE-RECEPTOR
INDUCTION OF AN OLFACTORY MEMORY BY THE ACTIVATION OF A METABOTROPIC GLUTAMATE-RECEPTOR
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DOI：
10.1126/science.8023145
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发表时间：
1994-07-08
期刊：
影响因子：
56.9
通讯作者：
NAKANISHI, S
中科院分区：
文献类型：
--
作者：
KABA, H;HAYASHI, Y;NAKANISHI, S
雌性老鼠在交配时会对雄性信息素形成嗅觉记忆;交配后接触陌生雄性的信息素会阻止怀孕。这种记忆的形成是由辅助嗅觉系统介导的，其中交配后去甲肾上腺素的增加减少了γ-氨基丁酸从颗粒细胞到二尖瓣细胞的抑制性传递。这项研究表明，激活mGluR 2，代谢型谷氨酸受体，抑制γ-氨基丁酸抑制的二尖瓣细胞，允许形成一个特定的嗅觉记忆，而不发生交配的mGluR 2激动剂注入女性的副嗅球。这种记忆忠实地反映了交配时形成的记忆。
Female mice form an olfactory memory of male pheromones at mating; exposure to the pheromones of a strange male after that mating will block pregnancy. The formation of this memory is mediated by the accessory olfactory system, in which an increase in norepinephrine after mating reduces inhibitory transmission of gamma-aminobutyric acid from the granule cells to the mitral cells. This study shows that the activation of mGluR2, a metabotropic glutamate receptor that suppresses the gamma-aminobutyric acid inhibition of the mitral cells, permits the formation of a specific olfactory memory without the occurrence of mating by infusion of mGluR2 agonists into the female's accessory olfactory bulb. This memory faithfully reflects the memory formed at mating.